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Aerobic exercise for Mild Cognitive Impairment (GEMSII Trial)

N/A
Waitlist Available
Led By Thomas O Obisesan, MD, MPH
Research Sponsored by Howard University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change in lipids (mg/dl) from baseline at 3 month, 6 month, 9 month, 12 month and 18 month
Awards & highlights

GEMSII Trial Summary

This trial will compare the effects of aerobic exercise to stretch exercise in community-dwelling African American mild cognitively impaired subjects.

Eligible Conditions
  • Mild Cognitive Impairment

GEMSII Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change in nuclear magnetic resonance (nmr) spectroscopy measured lipids concentrations (nml/l) from baseline at 3 month, 6 month, 9 month, 12 month and 18 month
This trial's timeline: 3 weeks for screening, Varies for treatment, and change in nuclear magnetic resonance (nmr) spectroscopy measured lipids concentrations (nml/l) from baseline at 3 month, 6 month, 9 month, 12 month and 18 month for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Neuropsychological assessments
Secondary outcome measures
Alzheimer's disease-related markers and biomarkers and their gene-environment interactions.
Alzheimer's disease-related markers and biomarkers assessed by change in CSF levels of Tau (ng/L) and Abeta (ng/L)
Alzheimer's Disease
+7 more

GEMSII Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Aerobic ExerciseExperimental Treatment1 Intervention
6-month 3-time/week aerobic exercise, and a 12-month passive follow-up.
Group II: Stretch ExerciseActive Control1 Intervention
6-month 3-time/week stretch exercise, and a 12-month passive follow-up.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Aerobic exercise
2000
Completed Phase 2
~1130

Find a Location

Who is running the clinical trial?

Howard UniversityLead Sponsor
39 Previous Clinical Trials
13,163 Total Patients Enrolled
University of Southern CaliforniaOTHER
906 Previous Clinical Trials
1,596,208 Total Patients Enrolled
University of California, San DiegoOTHER
1,121 Previous Clinical Trials
1,520,844 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Genes, Exercise, Neurocognitive and Neurodegeneration: Community-Based Approach
2014. "Genes, Exercise, Neurocognitive and Neurodegeneration: Community-Based Approach". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02614365.
~7 spots leftby Apr 2025
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