Magnetic Resonance Elastography for Brain Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores a new imaging technique called magnetic resonance elastography (MRE), which might help surgeons determine the best approach for operating on brain tumors by assessing their consistency. Researchers compare MRE to standard MRI scans to evaluate if it provides better information for surgical planning. The trial seeks participants scheduled for brain tumor surgery at the Keck Medical Center of USC. This study might be suitable for those with a brain tumor who are due for surgery, unless they have issues undergoing MRI scans. As an unphased trial, it offers a unique opportunity to contribute to the advancement of surgical planning techniques for brain tumors.
Do I need to stop my current medications for this trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What prior data suggests that this imaging technique is safe for brain cancer patients?
Research has shown that magnetic resonance elastography (MRE) is safe for people. MRE is a non-invasive imaging method, meaning it doesn't involve surgery or entering the body. It uses sound waves and magnets, like a regular MRI, to measure the stiffness of brain tumors.
One study examined data from 512 brain tumor patients and found that MRE was effective and did not cause harm. Since MRE doesn't involve any treatment or medication, the risk of side effects remains very low. It simply provides clearer pictures of the brain to help doctors plan surgeries better.
Overall, MRE is well-tolerated and considered safe based on current research.12345Why are researchers excited about this trial?
Researchers are excited about using Magnetic Resonance Elastography (MRE) for brain cancer because it offers a unique way to assess tumor consistency and stiffness. Unlike traditional imaging methods like MRI, which primarily provide detailed pictures of the brain, MRE adds another layer of information by measuring the mechanical properties of the tumor. This could help surgeons better plan their approach by knowing more about the tumor's texture before surgery, potentially leading to more precise and effective procedures. Additionally, this technique is non-invasive and can be seamlessly integrated with standard pre-operative MRI scans, making it a convenient addition to current diagnostic practices.
What evidence suggests that magnetic resonance elastography is effective for brain cancer?
Research has shown that magnetic resonance elastography (MRE), which participants in this trial will undergo, can measure the stiffness or softness of brain tumors. Studies have found that MRE effectively provides a noninvasive view of a tumor's firmness, assisting doctors during surgery. This technique may help predict surgical challenges, aiding in planning the best approach. Reviews have highlighted MRE's potential to offer valuable information for patients with brain tumors. By comparing MRE results with standard MRI, MRE could provide more detailed insights into the nature of a tumor.13678
Who Is on the Research Team?
Mark S Shiroishi, MD
Principal Investigator
University of Southern California
Are You a Good Fit for This Trial?
This trial is for adults over 18 with brain tumors who are scheduled for surgical removal at Keck Medical Center of USC. It's not suitable for those unable to undergo MRE or MRI, including individuals with metal implants, claustrophobia, a large body size, minors, pregnant women, state wards, and prisoners.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Pre-operative Imaging
Participants undergo MRE scan over 25 minutes before surgery at the time of standard of care pre-operative MRI scan
Surgery and Tumor Grading
On the day of surgery, the surgeon grades and records tumor consistency/stiffness during the operation and afterwards
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Magnetic Resonance Elastography
Magnetic Resonance Elastography is already approved in United States, European Union for the following indications:
- Diagnostic imaging for gliomas
- Assessment of tissue stiffness in radiation necrosis and recurrent glioma
- Diagnostic imaging for gliomas
- Assessment of tissue stiffness in radiation necrosis and recurrent glioma
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Southern California
Lead Sponsor
National Cancer Institute (NCI)
Collaborator