Magnetic Resonance Elastography for Brain Cancer

Overseen By Janet Jaime

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: University of Southern California

Disqualifiers: Children, Pregnant, Prisoners, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Approved in 2 Jurisdictions This treatment is already approved in other countries

Compensation: Varies

Number of Visits: 2

What You Need to Know Before You Apply

What is the purpose of this trial?

This clinical trial tests whether a new imaging technique called magnetic resonance elastography (MRE) is useful in determining the consistency of brain tumors and whether this could be used to guide surgical planning and choice of approach (the type of surgery that is needed) for patients with brain tumors. Comparing MRE with the typical magnetic resonance imaging (MRI) scan may help researchers assess the quality, reliability, and diagnostic utility of this scan when evaluating brain tumors.

Who Is on the Research Team?

Mark S Shiroishi, MD

Principal Investigator

University of Southern California

Are You a Good Fit for This Trial?

This trial is for adults over 18 with brain tumors who are scheduled for surgical removal at Keck Medical Center of USC. It's not suitable for those unable to undergo MRE or MRI, including individuals with metal implants, claustrophobia, a large body size, minors, pregnant women, state wards, and prisoners.

Inclusion Criteria

I am 18 or older and had brain tumor surgery at Keck Medical Center of USC.

Exclusion Criteria

Children under the age of 18, pregnant women, wards of the state, and prisoners

Patients who cannot tolerate MRE

I am not having surgery to remove a brain tumor.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Pre-operative Imaging

Participants undergo MRE scan over 25 minutes before surgery at the time of standard of care pre-operative MRI scan

1 day

1 visit (in-person)

Surgery and Tumor Grading

On the day of surgery, the surgeon grades and records tumor consistency/stiffness during the operation and afterwards

1 day

1 visit (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

6 weeks

What Are the Treatments Tested in This Trial?

Interventions

• Magnetic Resonance Elastography

Trial Overview The study is testing magnetic resonance elastography (MRE), a new imaging technique to measure brain tumor consistency. This will be compared with standard MRI scans to see if it can improve surgical planning.

How Is the Trial Designed?

Group I: Diagnostic (MRE, tumor grading) Experimental Treatment 2 Interventions

Patients undergo MRE scan over 25 minutes before surgery at the time of standard of care pre-operative MRI scan. On the day of surgery, the surgeon grades and records tumor consistency/stiffness during the operation and afterwards.

Magnetic Resonance Elastography is already approved in United States, European Union for the following indications:

Approved in United States as Magnetic Resonance Elastography for:

• Diagnostic imaging for gliomas
• Assessment of tissue stiffness in radiation necrosis and recurrent glioma

Approved in European Union as Magnetic Resonance Elastography for:

• Diagnostic imaging for gliomas
• Assessment of tissue stiffness in radiation necrosis and recurrent glioma

Who Is Running the Clinical Trial?

University of Southern California

Lead Sponsor

Trials

956

Recruited

1,609,000+

National Cancer Institute (NCI)

Collaborator

Trials

14,080

Recruited

41,180,000+