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Post Feraheme Infusion MRI for Glioblastoma

Phase < 1
Waitlist Available
Led By Seyed Ali Nabavizadeh, MD
Research Sponsored by Abramson Cancer Center at Penn Medicine
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 years
Awards & highlights

Study Summary

This study is evaluating whether a blood test can detect tumor cells in the blood.

Eligible Conditions
  • Glioblastoma
  • Brain Cancer
  • Brain Tumor

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Macrophage quantification status
Secondary outcome measures
Cell free tumor DNA (ctDNA)

Side effects data

From 2018 Phase 2 trial • 43 Patients • NCT02141490
3%
Hypertension
3%
Flushing
3%
Stomach pain
3%
Rash acneiform
3%
White blood cell decreased
3%
Nervous system disorders - Other, "Warm feeling"
100%
80%
60%
40%
20%
0%
Study treatment Arm
Prostate Cancer
Kidney Cancer
Bladder Cancer

Trial Design

1Treatment groups
Experimental Treatment
Group I: Ferumoxytol Infused MRIExperimental Treatment1 Intervention
Ferumoxytol is an iron replacement product that is FDA approved to treat iron deficiency anemia in patients with chronic kidney disease (CKD). In this study, ferumoxytol is used to quantify tumor-associated macrophages. The infused dose would be 5mg/kg.

Find a Location

Who is running the clinical trial?

Abramson Cancer Center at Penn MedicineLead Sponsor
387 Previous Clinical Trials
145,664 Total Patients Enrolled
7 Trials studying Glioblastoma
275 Patients Enrolled for Glioblastoma
Abramson Cancer Center of the University of PennsylvaniaLead Sponsor
359 Previous Clinical Trials
105,064 Total Patients Enrolled
7 Trials studying Glioblastoma
275 Patients Enrolled for Glioblastoma
Seyed Ali Nabavizadeh, MDPrincipal InvestigatorUniversity of Pennsylvania
1 Previous Clinical Trials
2 Total Patients Enrolled
1 Trials studying Glioblastoma
2 Patients Enrolled for Glioblastoma

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Multimodality MRI and Liquid Biopsy in GBM
Ali Nabavizadeh 2022. "Multimodality MRI and Liquid Biopsy in GBM". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04776980.
~0 spots leftby Apr 2025
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