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Non-disease controls (Training cohort) for Colorectal Cancer (ENCODE Trial)

N/A
Recruiting
Led By Ajay Goel, PhD
Research Sponsored by City of Hope Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up through study completion, an average of 1 year
Awards & highlights

ENCODE Trial Summary

Colorectal cancer (CRC) once predominantly affected older individuals, but in recent years has witnessed a progressive increase in incidence among young adults. Once rare, early-onset colorectal cancer (EOCRC, that is, a CRC diagnosed before the age of 50) now constitutes 10-15% of all newly diagnosed CRC cases and it stands as the first cause of cancer-related death in young men and the second for young women. This study aims to detect EOCRC with a non-invasive test, using a blood-based molecular assay based on microRNA (ribonucleic acid)

Eligible Conditions
  • Colorectal Cancer

ENCODE Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~through study completion, an average of 1 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion, an average of 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Sensitivity
Secondary outcome measures
Proportion of correct predictions (true positives and true negatives) among the total cases (i.e., accuracy)
Specificity

ENCODE Trial Design

4Treatment groups
Experimental Treatment
Group I: Non-disease controls (Validation cohort)Experimental Treatment1 Intervention
Individuals free from colorectal cancer, younger than 50 years of age
Group II: Non-disease controls (Training cohort)Experimental Treatment1 Intervention
Individuals free from colorectal cancer, younger than 50 years of age
Group III: Early onset colorectal cancer (Validation cohort)Experimental Treatment1 Intervention
Colorectal cancer diagnosed before the age of 50
Group IV: Early onset colorectal cancer (Training cohort)Experimental Treatment1 Intervention
Colorectal cancer diagnosed before the age of 50

Find a Location

Who is running the clinical trial?

City of Hope Medical CenterLead Sponsor
565 Previous Clinical Trials
1,921,060 Total Patients Enrolled
Ajay Goel, PhDPrincipal InvestigatorCity of Hope Medical Center
6 Previous Clinical Trials
3,977 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
CA: A Cancer Journal for CliniciansJournal
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries
Sung, Hyuna, Jacques Ferlay, Rebecca L. Siegel, Mathieu Laversanne, Isabelle Soerjomataram, Ahmedin Jemal, and Freddie Bray. 2021. “Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries”. CA: A Cancer Journal for Clinicians. Wiley. doi:10.3322/caac.21660.
clinicaltrials.govStudy
Early Onset Colorectal Cancer Detection
2023. "Early Onset Colorectal Cancer Detection". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06342401.
All > Anaheim > Paid Studies Ventura
~183 spots leftby Apr 2025
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