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Menadione Lotion for Cancer-Related Skin Discomfort

N/A

Waitlist Available

Research Sponsored by Mayo Clinic

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Age 18 years or older

Ability to reliably apply Menadione Topical Lotion / placebo twice a day to the face

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 8 weeks

Awards & highlights

Study Summary

This trial tests a lotion made from a vitamin to see if it can prevent skin problems and psychological distress in cancer patients receiving certain treatments.

Who is the study for?

Adults starting or within 3 days of beginning treatment with panitumumab, erlotinib hydrochloride, or cetuximab for cancer. Participants must be able to apply lotion twice daily and complete questionnaires. Excluded are those using certain skin treatments, pregnant or nursing women, and individuals not practicing contraception.Check my eligibility

What is being tested?

The trial is testing menadione topical lotion versus a placebo to see if it can prevent skin discomfort and reduce psychological distress in patients treated with specific cancer drugs. It includes applying the lotion regularly and answering questionnaires about their condition.See study design

What are the potential side effects?

While the side effects of menadione topical lotion aren't detailed here, typical concerns may include local skin reactions like redness or irritation at the site of application.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am 18 years old or older.

Select...

I can apply a lotion to my face twice daily without help.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 8 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 8 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 8 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Face

Secondary outcome measures

Long-term Cutaneous Discomfort as Measured by the Change From Baseline in Face Pain Scale at 4 Weeks (Treatment-regimen Estimand)

Long-term Psychosocial Discomfort as Measured by the Change From Baseline in Psychological Distress Score at 4 Weeks (Treatment-regimen Estimand)

The Number of Patients Experiencing Worst Toxicity

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Arm I (lotion)Experimental Treatment3 Interventions

Patients apply menadione topical lotion BID for 28 days.

Group II: Arm II (placebo)Placebo Group2 Interventions

Patients apply topical placebo lotion BID for 28 days.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

management of therapy complications

2008

Completed Phase 3

~3940

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

Mayo ClinicLead Sponsor

3,205 Previous Clinical Trials

3,766,757 Total Patients Enrolled

31 Trials studying Pain

5,781 Patients Enrolled for Pain

Aminah Jatoi, M.D.Study ChairMayo Clinic

9 Previous Clinical Trials

372 Total Patients Enrolled

1 Trials studying Pain

9 Patients Enrolled for Pain

Media Library

Menadione Topical Lotion (Other) Clinical Trial Eligibility Overview. Trial Name: NCT01393821 — N/A

Pain Research Study Groups: Arm II (placebo), Arm I (lotion)

Pain Clinical Trial 2023: Menadione Topical Lotion Highlights & Side Effects. Trial Name: NCT01393821 — N/A

Menadione Topical Lotion (Other) 2023 Treatment Timeline for Medical Study. Trial Name: NCT01393821 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many participants have been inducted into this research endeavor?

"Currently, this clinical trial is not open to new patients. The study was posted on January 1st 2012 and last edited on October 7th 2022. To find other studies recruiting participants suffering from pain, there are 2717 active trials while only one medical experiment admitting people who wish to use menadione topical lotion as a treatment option."

Answered by AI

What are the typical applications of menadione topical lotion?

"Menadione topical lotion can successfully address cases of factor ii deficiency, vitamin k insufficiency and general Vitamin K inadequacy."

Answered by AI

Are there any available slots remaining in this research project?

"This trial is no longer accepting participants; the initial posting was dated January 1st 2012 and it was last updated October 7th 2022. If you are hoping to join a medical study examining pain, there are currently 2717 trials recruiting patients for this purpose. Additionally, one clinical trial is looking for menadione topical lotion users to participate in their research program."

Answered by AI

Are there any previous experiments that have employed menadione topical lotion?

"Presently, there is one ongoing trial for menadione topical lotion with 0 trials in the final stage of research. Most studies are taking place in Phoenix, Arizona however two other sites have begun to conduct their own investigations."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Menadione Topical Lotion in Treating Skin Discomfort and Psychological Distress in Patients With Cancer Receiving Panitumumab, Erlotinib Hydrochloride, or Cetuximab

2012. "Menadione Topical Lotion in Treating Skin Discomfort and Psychological Distress in Patients With Cancer Receiving Panitumumab, Erlotinib Hydrochloride, or Cetuximab". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01393821.

All > Pain Management > Psychological