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Radiation Therapy

Stereotactic Radiosurgery (SRS) for Brain Tumor

N/A
Recruiting
Led By Chia-Lin Tseng, M.D.
Research Sponsored by Sunnybrook Health Sciences Centre
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 months, 4 months, 6 months, and 9 months
Awards & highlights

Study Summary

This study is evaluating whether whole brain radiation (WBRT) can be safely combined with stereotactic radiosurgery (SRS) for brain metastases.

Eligible Conditions
  • Brain Tumor

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 months, 4 months, 6 months, and 9 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 months, 4 months, 6 months, and 9 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Neurocognitive function
Secondary outcome measures
Distant tumour control within the brain
Incidence of Brain Salvage therapy During Follow-up
Local control of sites initially treated by SRS
+7 more

Side effects data

From 2020 Phase 1 & 2 trial • 30 Patients • NCT01120639
67%
Neoplasms benign, malignant and unspecified (incl cysts and polyps) - Other, death
50%
Headache
50%
Alopecia
17%
Seizure
17%
Syncope
17%
Nervous system disorders -Other, necrosis
17%
Nervous system disorders-Other, altered mental state
17%
Fatigue
100%
80%
60%
40%
20%
0%
Study treatment Arm
Stereotactic Radiosurgery (25 Gray x 5 Fractions)+Temozolomide
Stereotactic Radiosurgery (40 Gray x 5 Fractions)+Temozolomide
Stereotactic Radiosurgery (30 Gray x 5 Fractions)+Temozolomide
Stereotactic Radiosurgery (35 Gray x 5 Fractions)+Temozolomide

Trial Design

2Treatment groups
Experimental Treatment
Group I: SRS plus WBRTExperimental Treatment2 Interventions
Stereotactic radiosurgery plus whole brain radiation
Group II: SRSExperimental Treatment1 Intervention
Stereotactic radiosurgery
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Stereotactic Radiosurgery (SRS)
2012
Completed Phase 2
~240

Find a Location

Who is running the clinical trial?

Sunnybrook Health Sciences CentreLead Sponsor
656 Previous Clinical Trials
1,550,496 Total Patients Enrolled
Chia-Lin Tseng, M.D.Principal InvestigatorSunnybrook Health Sciences Centre

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Radiosurgery With or Without Whole Brain Radiation for Multiple Metastases
2020. "Radiosurgery With or Without Whole Brain Radiation for Multiple Metastases". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03775330.
~18 spots leftby Dec 2024
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