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Procedure

Direct Endoscopic Necrosectomy for Pancreatic Necrosis (DESTIN Trial)

N/A
Waitlist Available
Led By Shyam Varadarajulu, MD
Research Sponsored by AdventHealth
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 months
Awards & highlights

DESTIN Trial Summary

This trial is comparing two different ways to do surgery for infected pancreatitis.

Eligible Conditions
  • Pancreatic Necrosis

DESTIN Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Rate of treatment success
Secondary outcome measures
Number of Disease-related adverse events
Number of Procedure-related adverse events
Number of re-admissions
+9 more

DESTIN Trial Design

2Treatment groups
Active Control
Group I: Direct Endoscopic NecrosectomyActive Control1 Intervention
The subject will have endoscopic drainage and necrosectomy at the time of the index intervention.
Group II: Step-up Endoscopic InterventionsActive Control1 Intervention
The subject will only have endoscopic drainage of the pancreatic necrotic collection at the time of index intervention.

Find a Location

Who is running the clinical trial?

AdventHealthLead Sponsor
106 Previous Clinical Trials
29,526 Total Patients Enrolled
Shyam Varadarajulu, MDPrincipal InvestigatorAdventHealth
25 Previous Clinical Trials
5,891 Total Patients Enrolled
Muhammad Hasan, MDPrincipal InvestigatorAdventHealth
7 Previous Clinical Trials
1,183 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
GastroenterologyJournal
Burden of Gastrointestinal Disease in the United States: 2012 Update
Peery, Anne F., Evan S. Dellon, Jennifer Lund, Seth D. Crockett, Christopher E. McGowan, William J. Bulsiewicz, Lisa M. Gangarosa, et al.. 2012. “Burden of Gastrointestinal Disease in the United States: 2012 Update”. Gastroenterology. Elsevier BV. doi:10.1053/j.gastro.2012.08.002.
Gastrointestinal EndoscopyJournal
A Comparison of Direct Endoscopic Necrosectomy with Transmural Endoscopic Drainage for the Treatment of Walled-off Pancreatic Necrosis
Gardner, Timothy B., Prabhleen Chahal, Georgios I. Papachristou, Santhi Swaroop Vege, Bret T. Petersen, Christopher J. Gostout, Mark D. Topazian, Naoki Takahashi, Michael G. Sarr, and Todd H. Baron. 2009. “A Comparison of Direct Endoscopic Necrosectomy with Transmural Endoscopic Drainage for the Treatment of Walled-off Pancreatic Necrosis”. Gastrointestinal Endoscopy. Elsevier BV. doi:10.1016/j.gie.2008.06.061.
GutJournal
Non-superiority of Lumen-apposing Metal Stents over Plastic Stents for Drainage of Walled-off Necrosis in a Randomised Trial
Bang, Ji Young, Udayakumar Navaneethan, Muhammad K Hasan, Bryce Sutton, Robert Hawes, and Shyam Varadarajulu. 2018. “Non-superiority of Lumen-apposing Metal Stents over Plastic Stents for Drainage of Walled-off Necrosis in a Randomised Trial”. Gut. BMJ. doi:10.1136/gutjnl-2017-315335.
World Journal of SurgeryJournal
Natural Course of Acute Pancreatitis
Beger, H. G., B. Rau, J. Mayer, and U. Pralle. 1997. “Natural Course of Acute Pancreatitis”. World Journal of Surgery. Springer Science and Business Media LLC. doi:10.1007/s002689900204.
~2 spots leftby Apr 2025
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