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Behavioural Intervention

Strength Training with Blood Flow Restriction for Rheumatoid Arthritis

N/A

Waitlist Available

Led By Erin McCallister, DPT

Research Sponsored by Louisiana State University Health Sciences Center Shreveport

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up grip strength measurements are performed at 0, 4, and 8 weeks, and should take 2 minutes to complete

Awards & highlights

Study Summary

This trial will compare the effects of two different exercise programs on people with rheumatoid arthritis, osteoarthritis, or myositis. One exercise program is traditional and high-intensity, while the other is low-intensity with blood flow restriction. There will also be a control group who does no exercise. All groups will be measured for strength, function, and patient outcomes before and after the 8-week program, and then again at 6 and 12 months.

Who is the study for?

This trial is for individuals with rheumatoid arthritis, osteoarthritis, or myositis who have been on stable medication for at least 3 months and are cleared by a rheumatologist to participate in high-intensity training. They should not have cardiovascular diseases that prevent exercise, recent regular physical activity training, joint replacements in weight-bearing joints, high prednisone use, or inability to perform basic mobility tests.Check my eligibility

What is being tested?

The study compares traditional high-intensity strength training against low-intensity strength training with blood flow restriction. There's also a control group receiving no training. Participants' strength and function will be measured before the program starts, midway through it, at the end of the 8-week program and again after 6 and 12 months.See study design

What are the potential side effects?

While specific side effects aren't listed here since this is about exercise interventions rather than drugs; participants may experience muscle soreness or fatigue due to high-intensity workouts or discomfort from blood flow restriction bands.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ the 6 minute walk test is performed at 0, 4, and 8 weeks, and should take 6 minutes to complete.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~the 6 minute walk test is performed at 0, 4, and 8 weeks, and should take 6 minutes to complete.

This trial's timeline: 3 weeks for screening, Varies for treatment, and the 6 minute walk test is performed at 0, 4, and 8 weeks, and should take 6 minutes to complete. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Cardiovascular endurance walking test

Functional Strength by the Timed-up-and-Go test

Gait Speed

+2 more

Secondary outcome measures

Biceps muscle strength

Clinical Disease Activity Index (CDAI)

Grip Strength

+6 more

Side effects data

From 2008 Phase 3 trial • 34 Patients • NCT00879697

Gastrointestinal problems

Inguinal hernia

100%

80%

60%

40%

20%

Study treatment Arm

Strength Training

Walking Training

Trial Design

3Treatment groups

Experimental Treatment

Active Control

Group I: Traditional High-Intensity TrainingExperimental Treatment1 Intervention

Participants will perform their training at ~70% of their 1-repetition maximum, as traditionally advocated in strengthening literature. Each of the diagnoses (RA, OA, myositis) will have a High-Intensity arm.

Group II: Low Intensity plus Blood Flow Restriction TrainingExperimental Treatment1 Intervention

Participants will perform their training at ~30% of their 1-repetition maximum, and will have blood flow partially occluded (60-70%) to the training limb. Each of the diagnoses (RA, OA, myositis) will have a Low-Intensity plus Blood Flow Restriction arm.

Group III: ControlActive Control1 Intervention

Each of the diagnoses (RA, OA, myositis) will have a control arm. The control groups will be evaluated at time 0, 4 weeks, and 8 weeks but will not receive intervention.

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Louisiana State University Health Sciences Center ShreveportLead Sponsor

45 Previous Clinical Trials

17,215 Total Patients Enrolled

Erin McCallister, DPTPrincipal InvestigatorLSUHSC-Shreveport

2 Previous Clinical Trials

52 Total Patients Enrolled

Media Library

Low-Intensity Strengthening Program with Blood Flow Restriction (Behavioural Intervention) Clinical Trial Eligibility Overview. Trial Name: NCT04309227 — N/A

Muscle Weakness Research Study Groups: Control, Traditional High-Intensity Training, Low Intensity plus Blood Flow Restriction Training

Muscle Weakness Clinical Trial 2023: Low-Intensity Strengthening Program with Blood Flow Restriction Highlights & Side Effects. Trial Name: NCT04309227 — N/A

Low-Intensity Strengthening Program with Blood Flow Restriction (Behavioural Intervention) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04309227 — N/A

Muscle Weakness Patient Testimony for trial: Trial Name: NCT04309227 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this research include older adults as participants?

"This trial includes a wide age range of patients from 18 years old to 85 years old."

Answered by AI

If a patient is interested, can they enroll in this clinical trial currently?

"This particular study is no longer recruiting patients, however, this was last updated on July 1st, 2022. According to the same source, there are 1070 other trials that are still recruiting."

Answered by AI