Coronary computed tomography angiography (CCTA) for Coronary Artery Disease

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
NYU Langone Health, New York, NY
Coronary Artery Disease+4 More
Coronary computed tomography angiography (CCTA) - Procedure
Eligibility
18+
All Sexes
Eligible conditions
Select

Study Summary

This study is evaluating whether coronary inflammation is associated with non-obstructive coronary artery disease.

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Eligible Conditions

  • Coronary Artery Disease
  • Non Obstructive Coronary Atherosclerosis

Treatment Effectiveness

Effectiveness Progress

1 of 3

Other trials for Coronary Artery Disease

Study Objectives

This trial is evaluating whether Coronary computed tomography angiography (CCTA) will improve 3 primary outcomes in patients with Coronary Artery Disease. Measurement will happen over the course of Visit 1, Day 0.

Visit 1, Day 0
Perivascular coronary fat attenuation in patients with MINOCA will be greatest in the culprit coronary vessels with evidence of acute plaque disruption.
Perivascular coronary fat attenuation will be greater in INOCA patients with versus without coronary microvascular disease
Perivascular coronary fat attenuation will be significantly greater in MINOCA patients compared with INOCA patients

Trial Safety

Safety Progress

1 of 3

Other trials for Coronary Artery Disease

Trial Design

1 Treatment Group

Intervention group
1 of 1
Experimental Treatment

This trial requires 100 total participants across 1 different treatment group

This trial involves a single treatment. Coronary Computed Tomography Angiography (CCTA) is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Intervention groupParticipants will be identified by review of the cardiac catheterization laboratory schedule each day by the principal investigator, a co-investigator, or a research coordinator. Participants with no obstructive CAD and completed microvascular testing will undergo a research CCTA.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Metoprolol
FDA approved
Nitroglycerin
FDA approved
Iopamidol
FDA approved

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: visit 1, day 0
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly visit 1, day 0 for reporting.

Closest Location

NYU Langone Health - New York, NY

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 2 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Adult age ≥18 years referred for clinically indicated coronary angiography
Stable ischemic heart disease OR acute myocardial infarction as the indication for coronary angiography

Patient Q&A Section

How many people get coronary artery disease a year in the United States?

"About 300,000 cases of revascularization have been performed in the United States each year, making it the most common procedure performed on the patient population." - Anonymous Online Contributor

Unverified Answer

What are the signs of coronary artery disease?

"Coronary artery disease is associated with the development of angina. The most commonly observed changes in coronary artery stenosis occur in those with type 2 diabetes." - Anonymous Online Contributor

Unverified Answer

What is coronary artery disease?

"The following are the most common symptoms in a patient referred to an electrocardiogram (ECG): chest tightness, shortness of breath, palpitations, and atrial fibrillation. Other common symptoms in a patient referred for an ECG include: abnormal heart sounds or a fast or slow heart beat (palpitations and fainting), chest pain or shortness of breath. A common complaint in patients who present to the emergency department with chest pain includes: angina pectoris. The cause of a chest pain may be coronary artery disease, myocardial infarction, acute or chronic congestive heart failure, aortic dissection or valvular heart disease or anemia." - Anonymous Online Contributor

Unverified Answer

What are common treatments for coronary artery disease?

"Common treatments for coronary artery disease include antiestrogens, percutaneous coronary interventions, coronary angioplasty, coronary artery bypass graft surgery, and the use of beta-blockers or calcium channel blockers. Beta-blockers are frequently used for patients at high risk for coronary artery disease and may prevent future heart attacks and stroke. There is no cure for coronary artery disease and the aim of treatment is to reduce the symptoms of angina attacks and to improve health, preventing sudden cardiac death." - Anonymous Online Contributor

Unverified Answer

Can coronary artery disease be cured?

"Considering our observational data, the long-term outcome in patients with CAD is good for a population with a mean age of 66-75 years. The main obstacle for future treatment is the need of multidisciplinary teams, which might be a big challenge for most of Belgium's hospitals. The European Council emphasizes the need for adequate resources for a good management of patients at high risk of CAD." - Anonymous Online Contributor

Unverified Answer

What causes coronary artery disease?

"The cause of CAD is multi-factorial and is related to environmental, behavioural and environmental genetic factors, individual susceptibility, and individual experience. The risk can often be reduced by lifestyle and behavioural modifications." - Anonymous Online Contributor

Unverified Answer

Does coronary artery disease run in families?

"These case reports suggest that a significant proportion (10-30%) of older patients with a family history of CAD may unknowingly have a BRCA mutation due to a maternal or a paternal relation." - Anonymous Online Contributor

Unverified Answer

Does coronary computed tomography angiography (ccta) improve quality of life for those with coronary artery disease?

"Coronary ct angiography results in improved QoL in patients with stable, stable plus non-stable angina as compared to patients with stable angina who do not undergo coronary ct angiography." - Anonymous Online Contributor

Unverified Answer

What is the average age someone gets coronary artery disease?

"There are an unprecedented number of patients who have experienced CAD at an advanced stage of disease. It is important for physicians to be aware of this and to help patients at risk for CAD develop preventive measures." - Anonymous Online Contributor

Unverified Answer

How serious can coronary artery disease be?

"Clinically significant CAD occurs in approximately one quarter of PBC patients. Even in those with significant CAD there appears to be no significant increased mortality rate. In patients with PBC and severe CAD the main risk factors include cigarette smoking, elevated systolic blood pressure, low level of haemoglobin and the presence of esophageal varices." - Anonymous Online Contributor

Unverified Answer

What is the latest research for coronary artery disease?

"[The latest findings update the medical community about what we know and don't know about risk factors and prevention of coronary artery disease (CAD)(https://news.americanheart Association.org/news-center/articles/about-cad/overview)\n\nHeart disease accounts for more deaths each year in the United States than diabetes, lung disease, and cancer combined. It is a major cause of sudden death in young people. A coronary artery disease diagnosis is important because it indicates the presence of a blockage which needs to be addressed with treatment." - Anonymous Online Contributor

Unverified Answer

What is coronary computed tomography angiography (ccta)?

"Coronary computed tomography angiography can help locate arteries that are blocked, thereby helping physicians decide the best treatment for each patient. To find out if a specific procedure is a good option, run the power clinical trial page. The site collects patient numbers and then generates the results. If there is better test results then run the clinical trial. If the results are better than the existing ones, run the trial." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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