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Exercise Training for Heart Disease (EXCEED Trial)

N/A
Recruiting
Led By Jennifer Reed, PhD
Research Sponsored by Ottawa Heart Institute Research Corporation
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up from baseline to 12 weeks and baseline to 26 weeks
Awards & highlights

EXCEED Trial Summary

This trial is testing whether high-intensity interval training (HIIT) is better than moderate-intensity continuous exercise training (MICE) for improving exercise capacity and quality of life in women with coronary heart disease (CHD).

Who is the study for?
This trial is for English or French-speaking women with coronary heart disease who've had a related event or procedure at least 4 weeks ago but less than 12 weeks. They must be able to do an exercise test and have internet access. Women can't join if they have certain heart conditions, severe lung disease, are already exercising regularly, have unmanaged mental health issues, or can't commit to follow-up visits.Check my eligibility
What is being tested?
The study compares high-intensity interval training (HIIT) with moderate-intensity continuous exercise (MICE) in improving exercise capacity and quality of life in women with coronary heart disease. Participants will be randomly assigned to one of the two exercise programs.See study design
What are the potential side effects?
Exercise may cause temporary discomfort like muscle soreness or fatigue. High-intensity workouts could increase the risk of injury or cardiac events for those not accustomed to vigorous activity.

EXCEED Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~from baseline to 12 weeks and baseline to 26 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and from baseline to 12 weeks and baseline to 26 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Exercise capacity
Secondary outcome measures
Anxiety
COVID-19 Signs and Symptoms, Complications and Treatments
Depression
+12 more
Other outcome measures
Physical activity levels

EXCEED Trial Design

2Treatment groups
Experimental Treatment
Group I: standard care + moderate-intensity continuous exercise trainingExperimental Treatment1 Intervention
2 days/week Warm-up: 60-70% peak HR - 10min Training: 70-85% peak HR - 35min Cool-down: 60-70% peak HR - 15min
Group II: standard care + high-intensity interval trainingExperimental Treatment1 Intervention
2 days/week Warm-up: 60-70% peak HR - 10min Training: 85-95% peak HR - 25 minutes (4x4-minutes of high-intensity intervals interspersed with 3 minutes of low-intensity intervals) Cool-down: 60-70% peak HR - 10min
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Exercise
2016
Completed Phase 1
~760

Find a Location

Who is running the clinical trial?

Ottawa Heart Institute Research CorporationLead Sponsor
188 Previous Clinical Trials
92,264 Total Patients Enrolled
Jennifer Reed, PhDPrincipal InvestigatorOttawa Heart Institute Research Corporation
4 Previous Clinical Trials
110 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Exercise Training in Women With Heart Disease
Jennifer Reed 2021. "Exercise Training in Women With Heart Disease". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04781504.
All > Heart Disease
~43 spots leftby Apr 2025
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