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Procedure

Subchondroplasty and Knee Arthroscopy for Arthroscopy

N/A
Waitlist Available
Led By Alexander Rezansoff, MD, FRCSC
Research Sponsored by University of Calgary
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline (pre-surgery), 2 weeks, 3 months, 6 months, 12 months, 24 months post-surgery.
Awards & highlights

Study Summary

The primary objective of this randomized pilot study is to evaluate whether subchondroplasty combined with knee arthroscopy is more effective at reducing knee pain and improving knee function compared to knee arthroscopy alone. All knee function outcomes will be assessed at initial presentation, 3 months, 6 months, 12 months, and 24 months following surgery using validated questionnaires. Patient-reported pain will also be recorded at 2 weeks after surgery. The secondary objective of the study is to determine whether the subchondroplasty and knee arthroscopy group has better bone quality and bone micro-architecture compared to the group receiving knee arthroscopy alone. Bone quality/micro-architecture will be evaluated at baseline, 3 months, and 12 months following surgery using Magnetic resonance imaging (MRI) and High-Resolution Peripheral Quantitative CT (HR-pQCT) imaging and at baseline, 3 months, 12 months, and 24 months after surgery using X-rays.

Eligible Conditions
  • Arthroscopy
  • Osteoarthritis
  • Musculoskeletal Disorders
  • Subchondral Bone Edema
  • Bone Marrow Edema

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline (pre-surgery), 2 weeks, 3 months, 6 months, 12 months, 24 months post-surgery.
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline (pre-surgery), 2 weeks, 3 months, 6 months, 12 months, 24 months post-surgery. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Knee Injury and Osteoarthritis Outcome Score (KOOS) questionnaire scores
Secondary outcome measures
Change in International Knee Documentation Committee (IKDC) Subjective Knee Evaluation Form scores
Change in Patient-Reported Pain scores on the Visual Analog Scale (VAS)
Change in bone quality/micro-architecture evaluated using High-Resolution Peripheral Quantitative CT (HR-pQCT) imaging
+2 more

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: Subchondroplasty and Knee ArthroscopyActive Control2 Interventions
Patients randomized to the Subchondroplasty and Knee Arthroscopy group will receive the subchondroplasty procedure before or after knee arthroscopy that will be completed based on current standard of care guidelines.
Group II: Knee Arthroscopy AlonePlacebo Group1 Intervention
Patients randomized to the Knee Arthroscopy Alone group will receive the knee arthroscopy that will be completed based on current standard of care guidelines.

Find a Location

Who is running the clinical trial?

University of CalgaryLead Sponsor
791 Previous Clinical Trials
868,716 Total Patients Enrolled
McCaig Institute for Bone and Joint Health - Centre for Mobility and Joint HealthUNKNOWN
Alexander Rezansoff, MD, FRCSCPrincipal InvestigatorUniversity of Calgary

Frequently Asked Questions

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~3 spots leftby Apr 2025