This trial is evaluating whether Expiratory muscle strength therapy (EMST150, Aspire LLC) will improve 7 secondary outcomes in patients with Muscular Dystrophies. Measurement will happen over the course of Baseline measurement (week 0).
This trial requires 20 total participants across 2 different treatment groups
This trial involves 2 different treatments. Expiratory Muscle Strength Therapy (EMST150, Aspire LLC) is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are not being studied for commercial purposes.
"Muscular pathologies can be attributed on a wide range of mechanisms (e.g. genetic, hormonal and environmental factors), the most common being a primary genetic malfunction." - Anonymous Online Contributor
"There is one case of amyotrophic lateral sclerosis for every 40,000 to 200,000 US males and 1 case of myasthenia gravis for every 25,200 to 1.5 million US females between the ages of 15 and 74 years. The estimated incidence of muscle disease in US men and women is 2.6 and 2.2 per 100,000 person-years, respectively. The US Department of Health and Human Services (DHHS) estimates the annual direct costs of treating muscular diseases and conditions in 2002–2015 are about $24 billion. The estimated annual cost of these conditions in 2002–2015 is approximately $40 billion." - Anonymous Online Contributor
"It is generally accepted that muscular diseases result in weakness, weakness, or paralysis of the muscles used in the body's functional and physiological movements. These diseases can also cause spasm and twisting of muscles.\n" - Anonymous Online Contributor
"Muscle diseases can be treated with good effect: in all cases the muscles are better at function; in most cases quality of life will also improve. Muscle diseases can often be cured, but not all will fully recover, and the cure level depends much on the seriousness of the underlying disorder." - Anonymous Online Contributor
"This presentation defines the scope of treatment for muscular diseases, and is meant to stimulate the creation of novel treatments. Common treatments vary by disease, but often include physical therapy, splints, braces or orthoses; and, depending on the nature of the problem, medications can be used to treat or relieve symptoms, change bowel habits, or improve quality of life." - Anonymous Online Contributor
"Muscular diseases can be diagnosed using clinical and laboratory techniques. Muscles can be evaluated using biopsy, medical imaging, and electromyography (EMG). Treatment for most muscular diseases require a multiphoton plan, which allows for a combination of procedures for medical imaging and EMG evaluation. For EMG the most common and important procedure is for evaluation of the lower limb muscles." - Anonymous Online Contributor
"A multidisciplinary approach to treating COPD patients is urgently required because of increasing morbidity and mortality associated with this disease. This approach should include the use of emst150 technology. The use of emst150 in the clinical and research setting is safe, feasible, and promising for the therapeutic control of COPD." - Anonymous Online Contributor
"The majority of people (95%) reported improvements in muscle strength and physical function, and approximately 75% reported maintaining these improvements at 1 year of EMST150 treatment. However, more than half reported that their HRQoL worsened, perhaps indicating more urgent care in those who do not see progress on strength or physical function in 1-year follow-up." - Anonymous Online Contributor
"In general, our research has revealed that patients with muscular disorders have a higher mortality risks from cancers and cardiovascular diseases. This data is imperative for clinicians since patients with these disorders are especially susceptible to disease complications. Also, our findings demonstrate the importance of physical fitness in muscular disorders and emphasize the potential benefits of physical training programs in maintaining and enhancing muscle performance." - Anonymous Online Contributor
"This article presents the results of a randomized trial of EMST and placebo with the purpose of quantitatively assessing differences in exercise capacity and muscle strength between the two groups." - Anonymous Online Contributor
"All patients with a muscle disease or disorder should consider clinical trial participation, particularly for those at early stages of their illness or with comorbid conditions. Participation in clinical trials offers the benefits of the highest quality of medicine to the sickest patients." - Anonymous Online Contributor
"Results from a recent clinical trial show the efficacy of the EMD system in reducing exercise-induced larynx hyperpnea, dyspnea, and stridor in people with dysphagic dysphagia. Additional research is warranted to examine the potential use of the EMD system for muscle strength training." - Anonymous Online Contributor