Physical Activity (PA) Intervention for Multiple Sclerosis

Phase-Based Estimates
1
Effectiveness
1
Safety
The Hospital for Sick Children, Toronto, Canada
Multiple Sclerosis+2 More
Physical Activity (PA) Intervention - Behavioral
Eligibility
< 65
All Sexes
Eligible conditions
Multiple Sclerosis

Study Summary

This study is evaluating whether a smartphone app can help increase physical activity in youth with multiple sclerosis.

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Eligible Conditions

  • Multiple Sclerosis
  • Sclerosis
  • Pediatric Multiple Sclerosis

Treatment Effectiveness

Effectiveness Estimate

1 of 3

Study Objectives

This trial is evaluating whether Physical Activity (PA) Intervention will improve 1 primary outcome, 3 secondary outcomes, and 5 other outcomes in patients with Multiple Sclerosis. Measurement will happen over the course of Entire study - up to 18 months.

Month 18
Aerobic Capacity
Measures: Anxiety
Measures: Cognitive Function
Measures: Depression
Measures: Fatigue
Measures: Quality of Life
Physical Activity Level
Self-Reported PA Outcomes
Social Cognitive Theory Based Mediators of Physical Activity

Trial Safety

Safety Estimate

1 of 3

Trial Design

2 Treatment Groups

Control
Intervention

This trial requires 56 total participants across 2 different treatment groups

This trial involves 2 different treatments. Physical Activity (PA) Intervention is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Intervention
Behavioral
The participant receives the intervention immediately following baseline measurements.
ControlNo treatment in the control group
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Physical Activity (PA) Intervention
2019
N/A
~30

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: entire study - up to 18 months
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly entire study - up to 18 months for reporting.

Who is running the study

Principal Investigator
E. A. Y.
E. Ann Yeh, Senior Associate Scientist, Division of Neuroscience and Mental Health, SickKids Research Institute
The Hospital for Sick Children

Closest Location

The Hospital for Sick Children - Toronto, Canada

Eligibility Criteria

This trial is for patients born any sex aged 65 and younger. There are 3 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
MS is diagnosed in people who have experienced a single episode of neurologic symptoms that can include vision loss, weakness, numbness, and difficulty walking show original
People who don't participate in physical activity for more than three hours per week are more likely to be overweight or obese. show original
Youth 11-21 years of age;

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can multiple sclerosis be cured?

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With the current state of MS therapy, many patients can enjoy a normal life and minimize the disability they experience. If, however, the goal is complete rehabilitation of patients with MS, a cure is most likely impossible.

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What is multiple sclerosis?

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MS is an inflammatory disease typically affecting the optic nerve and brain. Both the brain and optic nerve can be affected. The most common symptoms in MS are worsening vision loss followed by brain problems. MS has several ways of looking at symptoms. \n

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What causes multiple sclerosis?

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A precise definition is needed to classify the etiology of MS. It is well established that most MS patients exhibit oligoclonal bands that are not found in healthy patients with otherwise similar clinical and radiological features. The underlying mechanisms involved are unknown and are the focus of intense research.

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What are the signs of multiple sclerosis?

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The presentation of MS is variable and depends on the type of disease process which is occurring in the CNS. The most common signs and symptom are numbness, weakness, pain and bladder dysfunction which may all occur at any time. Neurological examination of the entire body is necessary to make an accurate diagnosis.

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What are common treatments for multiple sclerosis?

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There is little evidence from systematic reviews about the treatment of multiple sclerosis and some of the reported treatments (such as antiviral agents and immunosuppressants) have only been reported in case reports or pilot studies. The use of corticosteroids for symptomatic relief, and their potential for inducing more serious side effects (e.g. diabetes insipidus) should be considered.

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How many people get multiple sclerosis a year in the United States?

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About 12 people are diagnosed with MS annually in the United States. This number is consistent with a current estimate of approximately 10,000 active MS patients in the U.S. at any given time.

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What are the common side effects of physical activity (pa) intervention?

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In summary, the major side effects of increased PA included increased fatigue, muscular cramps, and soreness. Regular exercise may be more appropriate for patients with low mobility deficits. Moderate exercise has a beneficial impact on sleep quality, depression, and fatigue, and the effect is possibly mediated by sleep-related factors. Further research is needed to determine the most effective duration of PA for a particular population and the optimum dose of exercise.

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What is the average age someone gets multiple sclerosis?

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This is a relatively new condition that is slowly becoming recognized and thus the average age for new patients is higher than originally thought. There are no reliable sources confirming the average age in various studies. The age of diagnosing multiple sclerosis has also changed: In a Danish study, patients who were younger at diagnosis (21.5 yr versus 27.9 yr) experienced a shorter interval until conversion (mean interval 4.8 yr) than the population-based cohorts (mean interval 6.6 yr). On average, patients younger than 36 yr at diagnosis experience a shorter interval between first symptoms and a diagnosis, and this is even more pronounced in the female group.

Unverified Answer

Does physical activity (pa) intervention improve quality of life for those with multiple sclerosis?

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PA intervention for MS patients leads to a significant improvement in various HRQoL domains. A more intensive PA intervention may have a broader effect on HRQoL, which may affect HRQoL and/or participation behaviour in an integrated rehabilitation setting.

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Is physical activity (pa) intervention safe for people?

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PA may reduce the risk of developing MS or NIND but there is a need to implement large-scale intervention studies on long-term consequences for long-term safety of an early/early PA intervention.

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Have there been other clinical trials involving physical activity (pa) intervention?

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This small pilot study suggests that PA intervention does not improve symptoms. Future studies using more robust and rigorous trial designs are indicated, incorporating the evaluation of PA type, duration, intensity and duration of intervention, duration of follow-up and the evaluation of a physical exercise intervention in the natural exercise environment.

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What is the latest research for multiple sclerosis?

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This article examines the current knowledge on MS by reviewing the most recent reports from 2012 to present. They offer general perspectives on the MS treatment that have emerged in the first half of the 21st century.

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