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Focused Ultrasound

Blood-Brain Barrier opening with MRgFUS for Amyotrophic Lateral Sclerosis

N/A
Waitlist Available
Led By Lorne Zinman, MD
Research Sponsored by InSightec
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up at the time of the exablate mrgfus procedure
Awards & highlights

Study Summary

This trial will test whether it is safe to open the blood-brain barrier using MRI-guided focused ultrasound in order to improve treatment for ALS.

Eligible Conditions
  • Amyotrophic Lateral Sclerosis

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~at the time of the exablate mrgfus procedure and 24 hours post-procedure
This trial's timeline: 3 weeks for screening, Varies for treatment, and at the time of the exablate mrgfus procedure and 24 hours post-procedure for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Safety - Device and Procedure related adverse events
Secondary outcome measures
Degree of contrast enhancement seen on post-procedure MRI

Trial Design

2Treatment groups
Experimental Treatment
Group I: Stage II CohortExperimental Treatment1 Intervention
Blood-Brain Barrier opening with MRgFUS. BBB opening of a larger volume of the primary motor cortex
Group II: Stage I CohortExperimental Treatment1 Intervention
Blood-Brain Barrier opening with MRgFUS. BBB opening of a small volume of the primary motor cortex

Find a Location

Who is running the clinical trial?

InSightecLead Sponsor
89 Previous Clinical Trials
3,706 Total Patients Enrolled
Lorne Zinman, MDPrincipal InvestigatorMedical Director, ALS/Neuromuscular Clinic, Sunnybrook Health Sciences Centre

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any remaining vacancies for enrolment in this experiment?

"Per the information on clinicaltrials.gov, this clinical trial has ceased recruitment of participants. It was first posted in April 2018 and last updated in September 2021; however, there are currently 540 other trials actively enrolling patients."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Blood-Brain Barrier Opening Using MR-Guided Focused Ultrasound in Patients With Amyotrophic Lateral Sclerosis
2018. "Blood-Brain Barrier Opening Using MR-Guided Focused Ultrasound in Patients With Amyotrophic Lateral Sclerosis". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03321487.
All > Lou Gehrigs Disease > Als
~1 spots leftby Apr 2025
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