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Corticosteroid

Alcohol vs Steroid Injections for Morton's Neuroma

N/A

Waitlist Available

Led By Christopher Digiovanni, MD

Research Sponsored by Brown University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

2 months of 2 or more of the following: Plantar pain increased by walking localized to the 2nd and 3rd interspaces, Relief of pain by resting, Pain radiating into toes, Numbness in toes or foot, Cramping in toes and foot

2 or more of the following physical findings: Plantar tenderness, Radiation of elicited pain into the toes, Palpable plantar mass, Numbness in toes, Exacerbation of symptoms with Mulder's maneuver

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 5 years

Awards & highlights

Study Summary

This trial will test whether serial ethanol injections are more effective than corticosteroid injections or lidocaine injections for treating interdigital neuroma pain.

Who is the study for?

This trial is for individuals with Morton's Neuroma, experiencing specific symptoms like plantar pain and toe numbness for at least 2 months. Participants should not have had previous treatments for neuroma or foot surgery, nor should they have other foot conditions such as bunions or nerve compression neuropathies.Check my eligibility

What is being tested?

The study compares three treatments: lidocaine injection (a numbing agent), corticosteroid injection (an anti-inflammatory medication), and ethanol injection (alcohol-based therapy) in patients with Morton's Neuroma. The effectiveness will be measured using questionnaires over a period of up to one year.See study design

What are the potential side effects?

Potential side effects may include temporary pain at the injection site, allergic reactions to the substances used, worsening of symptoms if treatment is ineffective, and rare complications from injections such as infection.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I have had foot pain, numbness, or cramping for 2 months.

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I have at least two symptoms like foot pain, numb toes, or a lump in my foot.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 5 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 5 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

1. Pain Scale

2. Physical function scale.

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

Brown UniversityLead Sponsor

456 Previous Clinical Trials

562,961 Total Patients Enrolled

Christopher Digiovanni, MDPrincipal InvestigatorRhode Island Hospital, Brown Medical School

Media Library

Corticosteroid Injection (Corticosteroid) Clinical Trial Eligibility Overview. Trial Name: NCT00284583 — N/A

Morton's Neuroma Clinical Trial 2023: Corticosteroid Injection Highlights & Side Effects. Trial Name: NCT00284583 — N/A

Corticosteroid Injection (Corticosteroid) 2023 Treatment Timeline for Medical Study. Trial Name: NCT00284583 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What criteria must be met to qualify for this research endeavor?

"This medical trial is open to 120 adults aged between 18 and 60 who have been diagnosed with morton's neuralgia. To qualify, participants must demonstrate the presence of numbness in their toes or foot as well as plantar pain when walking that originates from the 2nd and 3rd interspaces. Furthermore, they should display two or more indicators such as relief through rest, cramping in their feet/toes, tenderness on the soles of their feet, radiating pain into other toes and a palpable mass along the length of the sole."

Answered by AI

Are individuals aged over 30 accepted into the clinical trial?

"Prospective trial participants must meet the age criterion of 18-60 to be considered. Additionally, there are 3 trials for people under 18 years old and 16 studies available for those aged above 65."

Answered by AI

Is recruitment still in progress for this clinical experiment?

"According to clinicaltrials.gov, this study is no longer actively seeking candidates. The trial was initially published on May 1st 2005 and the last update came in January 2006; however, there are 18 other trials currently recruiting patients at present time."

Answered by AI

Recent research and studies

The Journal of Foot and Ankle SurgeryJournal

The Treatment of Intermetatarsal Neuromas with 4% Alcohol Sclerosing Injections

Dockery, Gary L.. 1999. “The Treatment of Intermetatarsal Neuromas with 4% Alcohol Sclerosing Injections”. The Journal of Foot and Ankle Surgery. Elsevier BV. doi:10.1016/s1067-2516(99)80040-4.

European RadiologyJournal

Treatment of Intermetatarsal Morton?s Neuroma with Alcohol Injection Under US Guide: 10-month Follow-up

Fanucci, Ezio, Salvatore Masala, Sebastiano Fabiano, Dario Perugia, Ettore Squillaci, Viviana Varrucciu, and Giovanni Simonetti. 2004. “Treatment of Intermetatarsal Morton?s Neuroma with Alcohol Injection Under US Guide: 10-month Follow-up”. European Radiology. Springer Science and Business Media LLC. doi:10.1007/s00330-003-2057-7.

Foot & Ankle InternationalJournal

Morton's Interdigital Neuroma: A Comprehensive Treatment Protocol

Bennett, Gordon L., Charles E. Graham, and Donald M. Mauldin. 1995. “Morton's Interdigital Neuroma: A Comprehensive Treatment Protocol”. Foot & Ankle International. SAGE Publications. doi:10.1177/107110079501601204.

Foot and Ankle ClinicsJournal