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TMS for Schizophrenia Hallucinations

N/A

Recruiting

Led By Mark Halko, PhD

Research Sponsored by Mclean Hospital

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Diagnosis of schizophrenia or schizoaffective disorder

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline

Awards & highlights

Study Summary

This trial will use transcranial magnetic stimulation (TMS) to study how hallucinations work in schizophrenia and whether or not the magnetic field can improve symptoms.

Who is the study for?

This trial is for individuals with schizophrenia or schizoaffective disorder. It's not suitable for those who've had substance use disorders recently, have ambidexterity, contraindications to TMS or MRI like neurological issues, head trauma with unconsciousness, seizures/epilepsy (or family history of it), metal in the brain/skull, implanted medical devices, or claustrophobia in MRI.Check my eligibility

What is being tested?

The study tests transcranial magnetic stimulation (TMS) as a noninvasive brain stimulation technique to understand and potentially improve hallucinations in schizophrenia. Participants will receive repetitive TMS (rTMS) or a sham version that mimics the procedure without actual stimulation.See study design

What are the potential side effects?

Possible side effects of rTMS include discomfort at the coil placement site on the scalp, headache, lightheadedness, and rare risk of seizure. The sham treatment may cause similar sensations due to placebo effect but does not involve active brain stimulation.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I have been diagnosed with schizophrenia or schizoaffective disorder.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Auditory Hallucination Rating Scale (AHRS) Scale (AHRS)

Positive and Negative Syndrome Scale (PANSS)

Scale for the Assessment of Positive Symptoms (SAPS)

+1 more

Trial Design

2Treatment groups

Active Control

Placebo Group

Group I: Active cerebellum rTMSActive Control1 Intervention

Cerebellar targeted iTBS, twice daily, one week.

Group II: Sham cerebellum rTMSPlacebo Group1 Intervention

Cerebellar targeted sham iTBS, twice daily, one week.

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

Mclean HospitalLead Sponsor

213 Previous Clinical Trials

21,626 Total Patients Enrolled

19 Trials studying Schizophrenia

1,354 Patients Enrolled for Schizophrenia

Beth Israel Deaconess Medical CenterOTHER

837 Previous Clinical Trials

13,010,204 Total Patients Enrolled

21 Trials studying Schizophrenia

1,934 Patients Enrolled for Schizophrenia

National Institute of Mental Health (NIMH)NIH

2,786 Previous Clinical Trials

2,689,699 Total Patients Enrolled

249 Trials studying Schizophrenia

89,367 Patients Enrolled for Schizophrenia

Media Library

Active cerebellum rTMS Clinical Trial Eligibility Overview. Trial Name: NCT05343598 — N/A

Schizophrenia Research Study Groups: Active cerebellum rTMS, Sham cerebellum rTMS

Schizophrenia Clinical Trial 2023: Active cerebellum rTMS Highlights & Side Effects. Trial Name: NCT05343598 — N/A

Active cerebellum rTMS 2023 Treatment Timeline for Medical Study. Trial Name: NCT05343598 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many individuals have thus far enlisted in this clinical investigation?

"Affirmative. Clinicaltrials.gov shows that the trial, which was initially published on October 13th 2021, is actively searching for participants. 68 individuals must be recruited from 1 medical facility in order to proceed with this research study."

Answered by AI

Is there still an opportunity to join this medical experiment?

"Data found on clinicaltrials.gov shows that this research study is still searching for participants; the posting was initially made on October 13th 2021 and revised most recently on August 10th 2022."

Answered by AI