This trial is evaluating whether YIV-906+Sorafenib will improve 1 primary outcome and 12 secondary outcomes in patients with Advanced Hepatocellular Carcinoma (HCC). Measurement will happen over the course of Continuously throughout the study until 28 days after treatment discontinuation.
This trial requires 125 total participants across 2 different treatment groups
This trial involves 2 different treatments. YIV-906+Sorafenib is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are in Phase 2 and have already been tested with other people.
"Results from a recent paper confirmed the strong antitumor activities of sorafenib and suggest that it may be used as monotherapy in hepatocellular carcinoma (HCC)." - Anonymous Online Contributor
"Histologically, HCC is the most common form of [liver cancer](https://www.withpower.com/clinical-trials/liver-cancer) (95%). Tumor staging: staging of the liver, a surgical procedure in which part or all of the liver is removed to treat the cancer. The word carcinoma means “having tumorous parts/growth”.\n" - Anonymous Online Contributor
"Around 20,400 new cases of carcinoma, hepatocellular are diagnosed a year in the USA. This accounts for around 18% of new cancer cases a year. The main sites of cancer are the liver and the stomach. The incidence of this cancer is significantly more in men and in persons with a family history of carcinoma. The risk of getting cancer is also proportional to the age: the risk of getting breast cancer is three times the one of getting carcinoma, hepatocellular in adolescence, young adulthood and the middle age. The mortality of cancer, hepatocellular increases significantly with age." - Anonymous Online Contributor
"There has been very little success in curing carcinoma, hepatocellular. This is due to the fact that the cancer often has not reached a stage at which surgery is curative." - Anonymous Online Contributor
"Liver cancer has four distinct forms that are differentiated by their location. Common forms of treatment are for curative purposes only and include surgery, chemotherapy, radiation therapy, and targeted therapy. For some tumors, such as HCC, adjuvant treatment has been shown to improve patient outcome." - Anonymous Online Contributor
"The signs of carcinoma, hepatocellular, vary among races and may depend on the size of the liver and the amount of fat in the liver." - Anonymous Online Contributor
"A wide variety of environmental agents may increase the risk of developing carcinoma, particularly cigarette and hepatitis B virus (HBV) infections. The exact mechanism by which environmental agents transform normal cells into carcinoma remains unclear.\n\nAlthough the genetic component of cancer is well understood, researchers are still unsure of the environmental factors in the development of cancer, including ionizing radiation, lifestyle, diet, and various chemical substances and substances in tobacco smoke. Tobacco smoking, the most significant cause of cancer and cancer death, is linked to a wide variety of diseases and other cancers, such as mouth cancer.\n\nA large number of human cancers are associated with the uncontrolled multiplication of cells." - Anonymous Online Contributor
"Patients with carcinoma, hepatocellular, living in Hong Kong have a better survival rate than those of other countries. However, this is still lower than that of non-cancerous, and it doesn't affect the quality of life of patients. Patients with carcinoma, hepatocellular, who live in Hong Kong seem to have more chances to be diagnosed earlier, though they didn't die in a hospital earlier than non-cancerous patients. The life expectancy of patients with carcinoma, hepatocellular, was statistically shorter than those of patients with non-cancerous disease." - Anonymous Online Contributor
"Recent findings suggests that HCC run in families; although, the exact genetic basis for these tumors has not been determined, asymptomatic carriers should be followed to confirm their carrier status." - Anonymous Online Contributor
"Recent findings indicate that a minority of patients with cancer are eligible for clinical trials regarding tumor therapy. However, a higher proportion of patients with cancer would be considered eligible for trials focused on the treatment of cancer cachexia." - Anonymous Online Contributor
"We have developed a novel formula to predict the possibility of HCC, based on the combination of the presence of HBsAg, AFP and liver cirrhosis. This is helpful in guiding treatment of HCC." - Anonymous Online Contributor
"Carcinoma, hepatocellular is the most common carcinoma of the liver, accounting for over 90 percent of reported hepatocellular cancers. Since the incidence of hepatocellular carcinoma is most likely to occur in middle-aged Caucasians or Caucasians of African descent, screening programs for hepatocellular cancer should be instituted as early as is feasible in these groups." - Anonymous Online Contributor