HIFT 3x/week for Metabolic Syndrome

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Western Colorado University, Gunnison, CO
Metabolic Syndrome+5 More
HIFT 3x/week - Behavioral
Eligibility
18+
All Sexes
Eligible conditions
Select

Study Summary

This study is evaluating whether a 12-week high-intensity functional training program can improve lipid profiles, insulin sensitivity, and endothelial function.

See full description

Eligible Conditions

  • Metabolic Syndrome
  • Endothelial Dysfunction
  • Atherogenic Dyslipidemia
  • Insulin Resistance

Treatment Effectiveness

Effectiveness Progress

1 of 3

Other trials for Metabolic Syndrome

Study Objectives

This trial is evaluating whether HIFT 3x/week will improve 14 primary outcomes, 4 secondary outcomes, and 2 other outcomes in patients with Metabolic Syndrome. Measurement will happen over the course of 24hrs post 12-week training completion.

24hrs post 12-week training completion
Comparison between groups of exercise enjoyment perception after 12 weeks of training.
Comparison between groups of the intention to continue their allocated intervention after 12 weeks of training.
Baseline and 48hrs post 12-week training completion
Mean change from baseline and comparison between groups in apolipoprotein B (ApoB) count after 12 weeks of training.
Mean change from baseline and comparison between groups in blood glucose (BG).
Mean change from baseline and comparison between groups in blood insulin (INS).
Mean change from baseline and comparison between groups in glycosylated hemoglobin (HbA1c) after 12 weeks of training.
Mean change from baseline and comparison between groups in maximal oxygen consumption (VO2max).
Mean change from baseline and comparison between groups in the Homeostatic Assessment of Insulin Resistance (HOMA-IR).
Mean change from baseline and comparison between groups in the cholesterol content of high-density lipoproteins (HDL-C).
Mean change from baseline and comparison between groups in the cholesterol content of low-density lipoproteins (LDL-C).
Mean change from baseline and comparison between groups in the cholesterol content of very low-density lipoproteins (VLDL-C).
Mean change from baseline and comparison between groups in the total cholesterol (TC) content of all lipoproteins.
Mean change from baseline and comparison between groups in the total triglyceride content of all lipoprotein classes (TG).
Mean change from baseline and comparison between groups in the triglyceride content of LDL (LDL-T).
Mean change from baseline and comparison between groups in the triglyceride content of VLDL (VLDL-T).
Mean change from baseline and comparison between groups of body fat mass percentage (FM%).
Mean change from baseline and comparison between groups of body lean mass percentage (LM%).
Mean change from baseline and comparison between groups of endothelial-dependent area under the curve (AUC) of hyperemia blood flow.
Mean change from baseline and comparison between groups of endothelial-dependent peak blood flow (PBF).
Mean change from baseline and comparison between groups of self-perceived fitness after 12 weeks of training.

Trial Safety

Safety Progress

1 of 3

Other trials for Metabolic Syndrome

Trial Design

3 Treatment Groups

HIFT 2x/week
1 of 3
HIFT 1x/week
1 of 3
HIFT 3x/week
1 of 3
Experimental Treatment

This trial requires 60 total participants across 3 different treatment groups

This trial involves 3 different treatments. HIFT 3x/week is the primary treatment being studied. Participants will be divided into 3 treatment groups. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

HIFT 2x/week
Behavioral
HIFT exercise performed two times per week.
HIFT 1x/week
Behavioral
HIFT exercise performed one time per week.
HIFT 3x/week
Behavioral
HIFT exercise performed three times per week.

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: baseline and 48hrs post 12-week training completion
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly baseline and 48hrs post 12-week training completion for reporting.

Closest Location

Western Colorado University - Gunnison, CO

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 2 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Physically inactive people who begin a program of moderate-intensity exercise three times a week for three months can lower their blood pressure, according to a study show original
The individual has at least three of the following five risk factors that are used to define metabolic syndrome: waist circumference that is greater than 102 cm for men or 88 cm for women, blood pressure that is 130/85 or higher when at rest, low levels of HDL cholesterol (less than 40 mg/dL for men or 50 mg/dL for women), high levels of triglycerides (150 mg/dL or more), and blood sugar levels that are 100 mg/dL or higher when fasting. show original

Patient Q&A Section

Does hift 3x/week improve quality of life for those with metabolic syndrome?

"Exercise intensity of 3XW improved QOL in those with MetS. Moreover, aerobic exercise was associated with significant decreases in BMI, waist circumference, systolic BP, and diastolic BP." - Anonymous Online Contributor

Unverified Answer

How many people get metabolic syndrome a year in the United States?

"About 9.7 million people meet the criteria of the metabolic syndrome, and there were about 31 million with 3 or more diagnostic criteria for the syndrome. Therefore, about 22.8% of the adults in the United States have this syndrome. There has been steady, moderate increase in the prevalence of both metabolic syndrome and its key components since 1980." - Anonymous Online Contributor

Unverified Answer

What are common treatments for metabolic syndrome?

"Given the lack of evidence in the literature regarding specific therapeutic options for people with metabolic syndrome, there is no evidence of a common set of treatments in most studies; therefore, there is no consensus about what is the most effective. However, there will be many treatments available, and there is a growing consensus that exercise should be considered for everyone with metabolic syndrome, and that lifestyle modifications are a core part of the multidisciplinary treatment of metabolic syndrome. To find active diabetes clinical trials in your area, you can use Power to search by condition, treatment, or location." - Anonymous Online Contributor

Unverified Answer

What are the signs of metabolic syndrome?

"MetS is a syndrome which affects multiple systems; thus the signs will be specific for those affected. It is very important for health care professionals to detect this syndrome early in patients' lives, and to help them lose and maintain weight." - Anonymous Online Contributor

Unverified Answer

Can metabolic syndrome be cured?

"MetS cannot be cured. The risk of progression in some men with MetS was significantly reduced. MetS-diagnosed men had lower rates of death from all causes and disease-related mortality than other men diagnosed with MetS." - Anonymous Online Contributor

Unverified Answer

What causes metabolic syndrome?

"MetS is not a genetic disease. It is a complex condition that is made up of multiple genetic and environmental factors. In addition metabolic syndrome was the second most common underlying chronic disease in this population." - Anonymous Online Contributor

Unverified Answer

What is metabolic syndrome?

"Metabolic syndrome is associated with an increased risk of type 2 diabetes and coronary heart disease. It appears to be a heterogeneous disorder with widely varying prevalence rates over the course of the year. We have demonstrated that the metabolic syndrome is of much higher prevalence the earlier in the year the blood sugar screening takes place. We also present significant association (p < 0.001) between metabolic syndrome, high BMI and hypertriglyceridemia." - Anonymous Online Contributor

Unverified Answer

What are the common side effects of hift 3x/week?

"This treatment has a good tolerability and seems to be effective against several metabolic, cardiovascular, and inflammatory effects. The improvement in some cardiometabolic parameters was maintained up to 4 weeks." - Anonymous Online Contributor

Unverified Answer

What is the primary cause of metabolic syndrome?

"MetS is not a single disease with identifiable causes. Rather, the occurrence of MetS is a complex interplay between lifestyle and genetic factors, and it is unclear what if any causal link exists between lifestyle habits and MetS." - Anonymous Online Contributor

Unverified Answer

Have there been any new discoveries for treating metabolic syndrome?

"The metabolic syndrome is being researched at the present time, and clinical trials for the treatment of hypertriglyceridemia are expected. The primary treatment for hypertriglyceridemia is a restrictive diet. On the other hand, clinical trials of new drugs for the treatment of hypertriglyceridemia have not yet started. As of 2012, there are a number of medications targeting glucose metabolism, and more clinical trials examining diabetes treatments are expected." - Anonymous Online Contributor

Unverified Answer

Who should consider clinical trials for metabolic syndrome?

"A substantial number of people who may be eligible for clinical trials do not currently participate. The high levels of interest and willingness for clinical trials may be due to concerns concerning weight loss and general well-being, which is not currently considered a risk factor for cardiovascular disease. These issues may be considered during the clinical trial screening process to avoid unnecessary exclusion of eligible patients." - Anonymous Online Contributor

Unverified Answer

What is the average age someone gets metabolic syndrome?

"The mean age for diagnosis in this study was 55.6 years compared to the general population average of 39.7 years. If we look a decade later, the mean age for diagnosis for the same age group will be about 37.9 years." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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