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Dietary Fatty Acids

Monounsaturated Fatty Acids Diet for Metabolic Syndrome

N/A
Waitlist Available
Led By Patrick Couture, MD, FRCP, PhD
Research Sponsored by Laval University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Men and women aged between 18-60 years
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up at week 4 and week 12 (at the end of the two 4-weeks diets)
Awards & highlights

Study Summary

This trial will investigate how replacing dietary saturated fatty acids with monounsaturated fatty acids reduces cardiovascular risk in people with insulin-resistance and dyslipidemia.

Who is the study for?
This trial is for men and women aged 18-60 with metabolic syndrome, characterized by high triglycerides, large waist circumference, elevated fasting blood glucose, low HDL cholesterol levels, and normal blood pressure. It excludes those on certain medications or with conditions affecting the study's integrity.Check my eligibility
What is being tested?
The trial tests how a diet rich in monounsaturated fatty acids (MUFAs) versus one high in saturated fatty acids (SFAs) affects intestinal lipid metabolism in insulin-resistant subjects to potentially reduce cardiovascular disease risk.See study design
What are the potential side effects?
While not explicitly listed, potential side effects may include changes in digestion or nutrient absorption due to dietary adjustments. Individual responses can vary based on personal health and metabolism.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am between 18 and 60 years old.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~at week 4 and week 12 (at the end of the two 4-weeks diets)
This trial's timeline: 3 weeks for screening, Varies for treatment, and at week 4 and week 12 (at the end of the two 4-weeks diets) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in TRL apolipoprotein B48 (apoB-48) production rate.
Secondary outcome measures
Change in synthesis of apoB-48 containing lipoproteins (Microsomal triglyceride transfer protein (MTP), apoB-48).
Changes in duodenal expression of Niemann-Pick C1-like 1, Adenosine triphosphate-binding cassette transporters, Fatty Acid Binding Protein, Sterol Regulatory Element Binding Protein.
Changes in duodenal expression of diacylglycerol acyltransferase, Acyl-CoA:cholesterol O-acyltransferase 2 and 3-hydroxy-methylglutaryl-CoA reductase.

Trial Design

2Treatment groups
Experimental Treatment
Group I: Saturated fatty acids dietExperimental Treatment2 Interventions
During 4 weeks, subjects eat a diet high in polyunsaturated fatty acids (percent of total caloric intake: 15.0% from proteins; 50.0% from carbohydrates; 35.0% from fat: 13.4% from saturated fat; 14.4% from monounsaturated fat; 7.2% from n-6 polyunsaturated fat).
Group II: Monounsaturated fatty acids dietExperimental Treatment2 Interventions
During 4 weeks, subjects eat a diet high in monounsaturated fatty acids (percent of total caloric intake: 15.0% from proteins; 50.0% from carbohydrates; 35.0% from fat: 7.1% from saturated fat; 20.7% from monounsaturated fat; 7.2% from n-6 polyunsaturated fat).

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Who is running the clinical trial?

Laval UniversityLead Sponsor
417 Previous Clinical Trials
172,234 Total Patients Enrolled
26 Trials studying Metabolic Syndrome
1,997 Patients Enrolled for Metabolic Syndrome
Canadian Institutes of Health Research (CIHR)OTHER_GOV
1,341 Previous Clinical Trials
26,452,675 Total Patients Enrolled
27 Trials studying Metabolic Syndrome
2,457 Patients Enrolled for Metabolic Syndrome
Patrick Couture, MD, FRCP, PhDPrincipal InvestigatorLaval University
5 Previous Clinical Trials
580 Total Patients Enrolled
2 Trials studying Metabolic Syndrome
50 Patients Enrolled for Metabolic Syndrome

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Effects of Monounsaturated Fatty Acids on Intestinal Lipid Metabolism in Insulin Resistant Subjects (MUFA )
Patrick Couture 2020. "Effects of Monounsaturated Fatty Acids on Intestinal Lipid Metabolism in Insulin Resistant Subjects (MUFA )". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03872349.
All > Metabolic Syndrome
~20 spots leftby Feb 2029
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