Mango consumption for Metabolic Syndrome

1
Effectiveness
1
Safety
Laval University, Québec, Canada
Metabolic Syndrome+1 More
Mango consumption - DietarySupplement
Eligibility
18 - 65
All Sexes
Eligible conditions
Metabolic Syndrome

Study Summary

This study is evaluating whether mango consumption can improve metabolic profile in overweight or obese individuals.

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Eligible Conditions

  • Metabolic Syndrome
  • Gut Microbiota

Treatment Effectiveness

Effectiveness Estimate

1 of 3

Study Objectives

This trial is evaluating whether Mango consumption will improve 6 primary outcomes and 19 secondary outcomes in patients with Metabolic Syndrome. Measurement will happen over the course of 8 weeks.

8 weeks
Changes in body mass index (BMI) of overweight/obese men and women taking frozen mangos daily
Changes in diastolic blood pressure of overweight/obese men and women taking frozen mangos daily
Changes in gene expression in peripheral blood mononuclear cells (PBMC) of overweight/obese men and women taking frozen mangos daily
Changes in glycated hemoglobin (HbA1c) in overweight/obese men and women taking frozen mangos daily
Changes in gut microbiota composition in overweight/obese men and women taking frozen mangos daily
Changes in hip circumference of overweight/obese men and women taking frozen mangos daily
Changes in insulin secretion of overweight/obese men and women taking frozen mangos daily
Changes in insulin sensitivity of overweight/obese men and women taking frozen mangos daily
Changes in plasma HDL cholesterol concentration of overweight/obese men and women taking frozen mangos daily
Changes in plasma LDL cholesterol concentration of overweight/obese men and women taking frozen mangos daily
Changes in plasma LPS binding protein (LBP) concentration of overweight/obese men and women taking frozen mangos daily
Changes in plasma glucose concentration of overweight/obese men and women taking frozen mangos daily
Changes in plasma high-sensitivity C-reactive protein (hs-CRP) concentration of overweight/obese men and women taking frozen mangos daily
Changes in plasma insulin concentration of overweight/obese men and women taking frozen mangos daily
Changes in plasma interleukin-6 (IL-6) concentration of overweight/obese men and women taking frozen mangos daily
Changes in plasma lipopolysaccharide (LPS) concentration of overweight/obese men and women taking frozen mangos daily
Changes in plasma metabolites concentration in overweight/obese men and women taking frozen mangos daily
Changes in plasma total cholesterol concentration of overweight/obese men and women taking frozen mangos daily
Changes in plasma triglycerides concentration of overweight/obese men and women taking frozen mangos daily
Changes in plasma tumor necrosis factor (TNF-alpha) concentration of overweight/obese men and women taking frozen mangos daily
Changes in systolic blood pressure of overweight/obese men and women taking frozen mangos daily
Changes in waist circumference of overweight/obese men and women taking frozen mangos daily
Changes in waist to hip circumference ratio of overweight/obese men and women taking frozen mangos daily
Changes in weight of overweight/obese men and women taking frozen mangos daily
Baseline
Height of overweight/obese men and women taking frozen mangos daily

Trial Safety

Safety Estimate

1 of 3

Trial Design

2 Treatment Groups

Control
Mango consumption

This trial requires 35 total participants across 2 different treatment groups

This trial involves 2 different treatments. Mango Consumption is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Mango consumption
DietarySupplement
ControlNo treatment in the control group

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 8 weeks
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 8 weeks for reporting.

Who is running the study

Principal Investigator
C. C.
Prof. Charles Couillard, Professor
Laval University

Closest Location

Laval University - Québec, Canada

Eligibility Criteria

This trial is for patients born any sex between 18 and 65 years old. There are 4 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Healthy men and premenopausal women
At least one of the following : BMI between 25 and 40 kg/m2 or Waist circumference ≥ 80 cm for women and ≥ 94 cm for men
At least one of the following : TG ≥ 1.35 mmol/L or fasting insulinemia ≥ 42 pmol/L
Caucasian origin

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the signs of metabolic syndrome?

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Metabolic syndrome is characterized by obesity, insulin resistance, dyslipidemia, a prothrombotic state and some changes in the hypothalamic-pituitary-adrenal axis. The diagnosis may be suspected by a high waist-to-hip ratio.

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Can metabolic syndrome be cured?

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Metabolic syndrome cannot be cured. Patients must be encouraged to get checked periodically with appropriate treatment, and patients with MetS need to keep healthy weight and reduce the level of LDL and hypertension to lower the mortality rate.

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What causes metabolic syndrome?

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Abetting on one hand the excess weight gain in an adult and on the other hand the insulin resistance may result in the onset of MS in individuals from different social groups, although not every person that develops MS has metabolic syndrome.

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How many people get metabolic syndrome a year in the United States?

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MetS was uncommon in the non-Hispanic black population. Higher prevalences in subgroups were observed compared to the whole population. Findings of the present study have highlighted important aspects regarding socioeconomic, geographic, racial and ethnic differences in MetS prevalence.

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What are common treatments for metabolic syndrome?

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Metabolic syndrome can lead to several complications. These include cardiovascular diseases, type 2 diabetes, sleep apnea, and infertility. Thus, treatment for metabolic syndrome is tailored to the specific patient to achieve the highest therapeutic benefit.

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What is metabolic syndrome?

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MetS is a syndrome that is defined by four components: central obesity, high blood pressure, high fasting and postprandial TG, and low HDL. MetS is found in many different age groups and racial groups. It is a highly prevalent disorder with the highest prevalence observed among the elderly, although its occurrence is increasing in other age groups.

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Is mango consumption safe for people?

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Data from a recent study suggest that a daily consumption of two or more servings of fruit provides no additional benefits in the control of LDL-C levels, glycemic control, or the incidence of CV disease (eg, MI, stroke or HF) in people without and with MetS. The safety of mango consumption may be further explored in clinical trials.

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What is the average age someone gets metabolic syndrome?

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[Metabolic syndrome]] occurs at about the age of 44-48. This information is helpful for [primary care providers] to understand and counsel patients with metabolic syndrome.

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What is the latest research for metabolic syndrome?

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There are several effective [treatments to decrease BMI, blood pressure, and cholesterol levels] (https://www.ncbi.nlm.nih.gov/books/bv.fcgi#health_competencies#cholesterol_and_metabolic_diseases_and_cohort_comparisons), but some treatment options are still not available in the clinic (https://www.nypcc.

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What are the common side effects of mango consumption?

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The consumption of ripe mangos at appropriate levels seems to be safe. Nevertheless, caution should be exercised when buying fresh mangos to consume (all fruits in their natural form should not be consumed) as they may contain tiny particles of aluminum, which can cause a mild metal poisoning in some people. [Power] Please seek advice from a personal health professional about appropriate use of mango and other fruits before beginning consumption.

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What is the primary cause of metabolic syndrome?

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There are four risk factors of metabolic syndrome including central adiposity, high blood pressure, high blood lipids, and low blood calcium. The central adiposity is the main cause of metabolic syndrome because it is the cause of central fat accumulation in the body. Other causes for metabolic syndrome are [high blood lipids (hyperlipidemia) and low blood calcium (hypocalcemia)]? This article will show how central adiposity causes metabolic syndrome.

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What are the latest developments in mango consumption for therapeutic use?

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This review describes recent research about the therapeutic benefits of mango consumption, while also highlighting potential adverse effects. Although more in vivo studies are required to elucidate the mechanisms of these potential adverse effects, it may be a matter of time before mango as food is routinely evaluated as a medicine.

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