Brown Fat Harvest During Anterior Neck Surgery for Obesity

University of New Mexico Health Sciences Center, Albuquerque, NM
Obesity+1 More ConditionsBrown Fat Harvest During Anterior Neck Surgery - Procedure
Eligibility
18 - 60
All Sexes

Study Summary

This trial is testing whether or not autophagy (a process where cells break down and recycle parts of themselves) plays a role in regulating browning of white adipose tissue (fat). The hypothesis is that autophagy mediates the beneficial effect of mTORC1 inhibition (a protein that helps control cell growth) on thermogenesis (heat production) in human brown adipocytes (a type of cell).

Eligible Conditions
  • Obesity
  • Metabolic Diseases

Treatment Effectiveness

Phase-Based Effectiveness

1 of 3
N/A

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Leuprolide acetate

Study Objectives

2 Primary · 0 Secondary · Reporting Duration: Up to six years after date of sample collection.

Up to six years after date of sample collection.
Gene transcript expression levels in lean and obese human brown adipose tissue samples will be quantified via quantitative Polymerase Chain Reaction and comparatively analyzed using a student T-test.
Protein expression levels in lean and obese human brown adipose tissue samples will be quantified via Western Blot and comparatively analyzed using a student T-test.

Trial Safety

Phase-Based Safety

1 of 3

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1
Deferred group - pioglitazone
1
Lifestyle Intervention
1
Leuprolide acetate

Awards & Highlights

No Placebo Group
All patients enrolled in this trial will receive the new treatment.

Trial Design

1 Treatment Group

Single Arm Study Group
1 of 1

Experimental Treatment

12 Total Participants · 1 Treatment Group

Primary Treatment: Brown Fat Harvest During Anterior Neck Surgery · No Placebo Group · N/A

Single Arm Study Group
Procedure
Experimental Group · 1 Intervention: Brown Fat Harvest During Anterior Neck Surgery · Intervention Types: Procedure
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Brown Fat Harvest During Anterior Neck Surgery
2016
N/A
~20

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: up to six years after date of sample collection.

Who is running the clinical trial?

University of New MexicoLead Sponsor
348 Previous Clinical Trials
3,539,431 Total Patients Enrolled
9 Trials studying Obesity
12,825 Patients Enrolled for Obesity
Meilian Liu, PhDPrincipal Investigator - University of New Mexico Biochemistry & Molecular Biology
University of New Mexico

Eligibility Criteria

Age 18 - 60 · All Participants · 3 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
Participants can be male or female.
Your body weight is either too low (lean) or too high (obese).
You do not have diabetes.
References

Frequently Asked Questions

Are individuals younger than 50 years old permitted to participate in this research?

"This clinical trial is seeking participants aged 18 to 60. Patients younger than 18 years old have 228 trials available, while those older than 65 can select from 666 different options." - Anonymous Online Contributor

Unverified Answer

Can I participate in this medical experiment?

"The current research seeks 32 individuals with metabolic diseases between 18 and 60. They must meet the following criteria: prepared for a procedure at UNMHSC, either gender, capacity to give informed consent, non-diabetic BMI <25 (slender) or >30 (overweight), bilingual English/Spanish speaker." - Anonymous Online Contributor

Unverified Answer

What is the maximum number of individuals that are allowed to partake in this experiment?

"Correct. According to records posted on clinicaltrials.gov, this clinical trial began recruiting patients in November 1st 2016 and was last revised on the 19th of December 2019. The study aims to enlist 32 individuals across a solitary medical centre." - Anonymous Online Contributor

Unverified Answer

Is recruitment for this trial currently underway?

"Affirmative, the clinicaltrials.gov webpage alludes to this medical trial currently recruiting patients. It was first announced on November 1st 2016 and last altered on December 19th 2019. 32 individuals are needed at a single site for participation in the study." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

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