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Brown Fat Harvest During Anterior Neck Surgery for Obesity (mTORHBFC Trial)

N/A

Waitlist Available

Led By Meilian Liu, PhD

Research Sponsored by University of New Mexico

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to six years after date of sample collection.

Awards & highlights

mTORHBFC Trial Summary

This trial is testing whether or not autophagy (a process where cells break down and recycle parts of themselves) plays a role in regulating browning of white adipose tissue (fat). The hypothesis is that autophagy mediates the beneficial effect of mTORC1 inhibition (a protein that helps control cell growth) on thermogenesis (heat production) in human brown adipocytes (a type of cell).

Eligible Conditions

Obesity
Metabolic Diseases

mTORHBFC Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to six years after date of sample collection.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to six years after date of sample collection.

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to six years after date of sample collection. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Gene transcript expression levels in lean and obese human brown adipose tissue samples will be quantified via quantitative Polymerase Chain Reaction and comparatively analyzed using a student T-test.

Protein expression levels in lean and obese human brown adipose tissue samples will be quantified via Western Blot and comparatively analyzed using a student T-test.

mTORHBFC Trial Design

1Treatment groups

Experimental Treatment

Group I: Single Arm Study GroupExperimental Treatment1 Intervention

Includes all consented patients, male and female, undergoing anterior cervical spine surgery, parathyroidectomy or thyroidectomy (18-60 years old), without history of diabetes mellitus and not pregnant or incarcerated.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Brown Fat Harvest During Anterior Neck Surgery

2016

N/A

~20

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Who is running the clinical trial?

University of New MexicoLead Sponsor

372 Previous Clinical Trials

3,528,777 Total Patients Enrolled

10 Trials studying Obesity

12,865 Patients Enrolled for Obesity

Meilian Liu, PhDPrincipal Investigator - University of New Mexico Biochemistry & Molecular Biology

University of New Mexico

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are individuals younger than 50 years old permitted to participate in this research?

"This clinical trial is seeking participants aged 18 to 60. Patients younger than 18 years old have 228 trials available, while those older than 65 can select from 666 different options."

Answered by AI

Can I participate in this medical experiment?

"The current research seeks 32 individuals with metabolic diseases between 18 and 60. They must meet the following criteria: prepared for a procedure at UNMHSC, either gender, capacity to give informed consent, non-diabetic BMI <25 (slender) or >30 (overweight), bilingual English/Spanish speaker."

Answered by AI

What is the maximum number of individuals that are allowed to partake in this experiment?

"Correct. According to records posted on clinicaltrials.gov, this clinical trial began recruiting patients in November 1st 2016 and was last revised on the 19th of December 2019. The study aims to enlist 32 individuals across a solitary medical centre."

Answered by AI

Is recruitment for this trial currently underway?

"Affirmative, the clinicaltrials.gov webpage alludes to this medical trial currently recruiting patients. It was first announced on November 1st 2016 and last altered on December 19th 2019. 32 individuals are needed at a single site for participation in the study."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

mTORC1 and Autophagy in Human Brown Adipocytes

Meilian Liu 2016. "mTORC1 and Autophagy in Human Brown Adipocytes". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04206124.