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Ultrasound Therapy

Low Intensity Focused Ultrasound Pulsation for Mental Illness (LIFUPEMOT Trial)

N/A
Waitlist Available
Research Sponsored by University of California, Los Angeles
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up day 1
Awards & highlights

LIFUPEMOT Trial Summary

This study is evaluating whether low intensity focused ultrasound pulsation may be able to help improve emotion regulation.

Eligible Conditions
  • Mental Illness
  • Post-Traumatic Stress Disorder
  • Mood Disorders
  • Social Anxiety
  • Cognitive Impairment
  • Anxiety Disorders

LIFUPEMOT Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~day 1
This trial's timeline: 3 weeks for screening, Varies for treatment, and day 1 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Emotion Reactivity
Secondary outcome measures
BOLD fMRI Signal in the Amygdala
Perfusion Arterial Spin Labeling (ASL) fMRI Signal throughout Brain

LIFUPEMOT Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: MRI ultrasound sonicationExperimental Treatment1 Intervention
Low Intensity focused ultrasound pulsation will be administered to participants while they are in the fMRI scanner. Functional and perfusion MRI data will be collected before and after the sonication to allow for comparisons and investigation of pre and post sonication functional activation and connectivity.
Group II: Sham UltrasoundPlacebo Group1 Intervention
While in the fMRI scanner, participants will have the ultrasound transducer attached to their head in the same manner as during the actual ultrasound sonication. However, during this portion of the experiment, the transducer will not be turned on. Previous, published experiments indicate that participants are unable to differentiate between when the transducer is on and off.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Low Intensity Focused Ultrasound Pulsation
2019
N/A
~30

Find a Location

Who is running the clinical trial?

University of California, Los AngelesLead Sponsor
1,528 Previous Clinical Trials
10,276,821 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who else is applying?

What state do they live in?
California
How old are they?
65+
What site did they apply to?
University of California, Los Angeles
What portion of applicants met pre-screening criteria?
Did not meet criteria
Recent research and studies
clinicaltrials.govStudy
Low Intensity Focused Ultrasound for Emotion Regulation
Taylor Kuhn 2019. "Low Intensity Focused Ultrasound for Emotion Regulation". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03782194.
~5 spots leftby Apr 2025
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