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Behavioral Intervention

Targeted Cognitive Training for High Risk for Psychosis

N/A
Waitlist Available
Led By Christine I Hooker, PhD
Research Sponsored by Rush University Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change in cognition from baseline (pre-intervention) to 10 weeks (post-intervention)
Awards & highlights

Study Summary

This trial is testing whether computer-based targeted cognitive training (TCT) can improve cognition and function in people at high risk for psychosis. TCT involves 40 hours of training in cognition and social cognition over 10 weeks. Cognition, social cognition, symptoms, and functioning will be assessed at baseline, after 20 hours/5 weeks of cognitive training (mid-intervention), and after 20 hours/5 weeks of social-cognitive training (post-intervention). Cognition, social cognition, symptoms, and functioning will also be assessed at a 9 month follow-up (i.e. 9 months after intervention completion).

Eligible Conditions
  • High Risk for Psychosis

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change in cognition from baseline (pre-intervention) to 10 weeks (post-intervention)
This trial's timeline: 3 weeks for screening, Varies for treatment, and change in cognition from baseline (pre-intervention) to 10 weeks (post-intervention) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery
Secondary outcome measures
Global Function: Social and Role Scales

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Targeted Cognitive TrainingExperimental Treatment1 Intervention
40 hours of computerized cognitive training
Group II: Computer GamesPlacebo Group1 Intervention
40 hours of computer games
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Targeted Cognitive Training
2017
N/A
~370

Find a Location

Who is running the clinical trial?

National Institute of Mental Health (NIMH)NIH
2,786 Previous Clinical Trials
2,689,553 Total Patients Enrolled
Beth Israel Deaconess Medical CenterOTHER
838 Previous Clinical Trials
13,010,353 Total Patients Enrolled
Rush University Medical CenterLead Sponsor
423 Previous Clinical Trials
163,984 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Targeted Cognitive Training in Clinical High Risk (CHR) for Psychosis
Christine Hooker 2015. "Targeted Cognitive Training in Clinical High Risk (CHR) for Psychosis". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02404194.
~14 spots leftby May 2025
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