THRIVE Intervention for Childhood Mental Disorder
Trial Summary
Will I have to stop taking my current medications?
The trial information does not specify whether participants need to stop taking their current medications.
How does the THRIVE treatment for childhood mental disorder differ from other treatments?
The THRIVE treatment, also known as Lynparza or Olaparib, is unique because it is primarily used for cancer treatment, specifically targeting cancer cells by inhibiting a protein involved in DNA repair. This mechanism is different from typical treatments for childhood mental disorders, which often involve antipsychotics or behavioral therapies.12345
What is the purpose of this trial?
This study is designed to test the effectiveness and implementation of an early intervention therapy for children and their primary caregivers by using existing school counselors across several school districts.The intervention is a 6-8 week caregiver-child intervention (THRIVE) which will be conducted via video conference in the family's home (i.e., zoom), or within the school setting (or a combination of those 2 modalities depending upon feasibility for the family). THRIVE will be compared to an asynchronous on-line parenting education program, Parenting Wisely (PW). This online parenting course will be accessed at www.parentingwisely.com.Existing school counselors will be trained in the delivery of THRIVE to 3-7 year old children (in preschool, kindergarten and first grade) and their primary caregivers. In addition to testing the effectiveness of THRIVE compared to PW, we will also compare two implementation strategies: THRIVE-Coached and THRIVE-Low Coached (LC). We will assess ongoing coaching of THRIVE trainees to increase therapist efficacy and adherence to the intervention (THRIVE-Coached). This will be compared to implementation of THRIVE with low supports (e.g. weekly supervision) provided only for the first case following the initial training (THRIVE-LC\].Compared to those randomized to PW, we expect children who receive THRIVE will have significantly better behavioral and socio-emotional outcomes. Caregivers who receive THRIVE will experience less parenting stress and depression, more optimism and will show more nurturing, emotional tolerance, and supportive caregiving.Therapists in the THRIVE-Coached condition will deliver the intervention with higher achieved outcomes and find the intervention to be more acceptable than therapists in the THRIVE-LC condition. Therapists in the THRIVE-Coached condition will be more likely to plan to sustain the intervention following the completion of the study than those in the THRIVE-LC condition. Parents and children receiving THRIVE from therapists in the THRIVE-Coached condition will have better socio-emotional outcomes than those in the THRIVE-LC and PW conditions.
Research Team
Joan Luby, PhD
Principal Investigator
Washington University School of Medicine
Eligibility Criteria
This trial is for children aged 3-7 who may be struggling with mental health issues, as indicated by their teachers or parents, but are not diagnosed with autism or major neurological disorders. Children already in weekly therapy are excluded.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Intervention
The THRIVE intervention is conducted over 6-8 weeks via video conference or within the school setting, compared to the Parenting Wisely online program.
Follow-up
Participants are monitored for behavioral and socio-emotional outcomes, as well as parenting stress and depression.
Treatment Details
Interventions
- Parenting Wisely
- THRIVE
Find a Clinic Near You
Who Is Running the Clinical Trial?
Washington University School of Medicine
Lead Sponsor