Treatment for Cannabis use

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Zuckerberg San Francisco General Hospital, San Francisco, CACannabis use+8 More
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

This trial will enroll experienced dual cannabis-tobacco smokers to study the effects of smoking and vaping dry herb cannabis. It will compare THC and toxicant exposure, subjective and cardiovascular effects, and cardiovascular disease risk between smoking cannabis and smoking tobacco cigarettes.

Eligible Conditions
  • Cannabis Use
  • Cannabis Smoking
  • Cannabis
  • Nicotine Addiction
  • Tetrahydrocannabinol
  • Smoking/Cigarette Smoking
  • Tobacco Use
  • Nicotine Withdrawal
  • Cardiovascular Risk

Treatment Effectiveness

Effectiveness Progress

1 of 3

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Study Objectives

15 Primary · 9 Secondary · Reporting Duration: Days 1-2 of each arm

Day 1
Area under the plasma concentration versus time curve (AUC)
Cardiovascular effects between cannabis products using heart rate as a measure
Cardiovascular effects between smoked tobacco and cannabis using heart rate as a measure
Peak plasma concentration
Time to peak plasma concentration
Toxicant exposure between smoked tobacco and cannabis using expired carbon monoxide as the measure
Day 2
Cardiovascular effects between smoked tobacco and cannabis using endothelial dysfunction as a measure
Cardiovascular effects between smoked tobacco and cannabis using epinephrine as a measure
Antioxidants
Cardiovascular effects between smoked tobacco and cannabis using platelet activation as a measure
Toxicant exposure between smoked tobacco and cannabis using mercapturic acid as the measure
Day 2
Cardiovascular effects between cannabis products using endothelial dysfunction as a measure
Cardiovascular effects between cannabis products using epinephrine as a measure
Cardiovascular effects between cannabis products using oxidant stress as a measure
Cardiovascular effects between cannabis products using platelet activation as a measure
Day 1
Puffing behaviors across all products
Subjective effects between cannabis products using the Drug Effects Questionnaire
Subjective effects between cannabis products using the Marijuana Cravings Questionnaire
Subjective effects between cannabis products using the Visual Analog Scale
Toxicant exposure between smoked tobacco and cannabis using use as a measure
Day 1
Area under the expired carbon monoxide (CO) curve (AUC)
Differences in metabolites of volatile organic compounds (VOCs)
Exposure to toxicants between cannabis products
Carbon monoxide

Trial Safety

Safety Progress

1 of 3

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Trial Design

0 Treatment Group

18 Total Participants · 0 Treatment Group

Primary Treatment: Treatment · No Placebo Group · N/A

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: days 1-2 of each arm

Who is running the clinical trial?

Tobacco Related Disease Research ProgramOTHER
22 Previous Clinical Trials
16,070 Total Patients Enrolled
University of California, San FranciscoLead Sponsor
2,312 Previous Clinical Trials
11,758,320 Total Patients Enrolled
Gideon St. Helen, PhDPrincipal InvestigatorUniversity of California, San Francisco
2 Previous Clinical Trials
37 Total Patients Enrolled

Eligibility Criteria

Age 18+ · All Participants · 3 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You use cannabis regularly by smoking joints or blunts at least three times a week for the past three months. You have also used a cannabis vaporizer before or are willing to use one during the study.
References

Frequently Asked Questions

Is this research endeavor recruiting participants presently?

"Yes, the information provided on clinicaltrials.gov shows that this research endeavour is actively enrolling patients. Originally posted 10/30/2020 and most recently updated 8/2/2022, 18 participants are being sought from 2 distinct sites." - Anonymous Online Contributor

Unverified Answer

What does this clinical experiment seek to achieve?

"The main outcome being monitored during the first two days of cannabis administration is maximal change in expired carbon monoxide levels. Secondary outcomes include assessing cardiovascular effects by measuring heart rate, comparing toxicant exposure through CO measurements, and examining epinephrine excretion via urine catecholamines." - Anonymous Online Contributor

Unverified Answer

How many participants are partaking in this scientific experiment?

"Affirmative. Clinicaltrials.gov data suggests that this medical trial, initially posted on October 30th 2020 is currently recruiting participants. 18 patients will be admitted at 2 study sites for the duration of the research project." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

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