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Non-invasive Brain Stimulation

Active rTMS for Cannabis Use Disorder

Phase 2
Waitlist Available
Led By Gregory Sahlem, MD
Research Sponsored by Stanford University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline (pre) and week-5 (post)
Awards & highlights

Study Summary

This trial will test if a high-frequency rTMS applied to the left dorsolateral prefrontal cortex can reduce behavioral craving and fMRI cue-reactivity in people with cannabis use disorder.

Eligible Conditions
  • Cannabis Use Disorder

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline (pre) and week-5 (post)
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline (pre) and week-5 (post) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Cue Reactivity
Marijuana Craving Questionnaire-Short Form Score as a Measure of Behavioral Craving
Secondary outcome measures
Abstinence

Side effects data

From 2022 Phase 2 trial • 72 Patients • NCT03144232
27%
Headache
16%
Fatigue
3%
Eye twitch
3%
Jaw Pain
3%
Site discomfort
100%
80%
60%
40%
20%
0%
Study treatment Arm
Repetitive Transcranial Magnetic Stimulation (rTMS)
Sham rTMS

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Active rTMSExperimental Treatment1 Intervention
10 Hz rTMS applied to the left DLPFC
Group II: Sham rTMSPlacebo Group1 Intervention
Sham rTMS applied to the left DLPFC
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Active rTMS
2019
Completed Phase 2
~350

Find a Location

Who is running the clinical trial?

National Institute on Drug Abuse (NIDA)NIH
2,469 Previous Clinical Trials
2,619,337 Total Patients Enrolled
Stanford UniversityLead Sponsor
2,395 Previous Clinical Trials
17,341,283 Total Patients Enrolled
Gregory Sahlem, MDPrincipal Investigator - Stanford University
Stanford University
7 Previous Clinical Trials
220 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
A Preliminary Investigation of Pre-Frontal Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Cannabis Use Disorder
Gregory Sahlem 2017. "A Preliminary Investigation of Pre-Frontal Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Cannabis Use Disorder". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03144232.
~9 spots leftby Apr 2025
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