Procedure
Intermittent Theta Burst Stimulation (iTBS) for Depression
Massachusetts General Hospital, Boston, MA
Intermittent Theta Burst Stimulation (iTBS)N/AWaitlist AvailableResearch Sponsored by Massachusetts General HospitalEligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Currently in a major depressive episode. Comorbid anxiety disorders and personality disorders will be allowed provided that MDD is the primary diagnosis.
Be older than 18 years old
Must not have
Be younger than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow ups5-10 minutes
Awards & highlights
Study Summary
This trial will investigate how stimulating specific brain networks with rTMS changes network connectivity and behavior, in order to establish more effective, individualized treatments for depression.
Eligible Conditions
- Depression
Eligibility Criteria
Inclusion Criteria
You will be eligible if you check “Yes” for the criteria belowSelect...
You are currently experiencing a severe episode of depression. If you also have anxiety or personality disorders, they are allowed as long as depression is the main issue.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow ups ~ 5-10 minutes
Screening ~ 3 weeks
Treatment ~ Varies
Follow ups ~ 5-10 minutes
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Applied Cognition-General Concerns scale
Blood oxygenation level dependent (BOLD) activation
Delayed Match to Sample Task
+11 moreTrial Design
6Treatment groups
Experimental Treatment
Placebo Group
Group I: vmPFC limbic-reward network targetExperimental Treatment1 Intervention
iTBS delivered four times daily to an individually defined reward network representation in left ventromedial prefrontal cortex (vMPFC).
Group II: dmPFC Default network B targetExperimental Treatment1 Intervention
iTBS delivered four times daily to an individually defined default network B representation in left dorsomedial prefrontal cortex (DMPFC).
Group III: DLPFC Salience network targetExperimental Treatment1 Intervention
iTBS delivered four times daily to an individually defined salience network representation in left dorsolateral prefrontal cortex (DLPFC).
Group IV: DLPFC Default network A targetExperimental Treatment1 Intervention
iTBS delivered four times daily to an individually defined default network A representation in left dorsolateral prefrontal cortex (DLPFC).
Group V: DLPFC Control network targetExperimental Treatment1 Intervention
iTBS delivered four times daily to an individually defined control network representation in left dorsolateral prefrontal cortex (DLPFC).
Group VI: SHAM stimulationPlacebo Group1 Intervention
SHAM iTBS delivered four times daily to an individually defined SHAM region in left dorsolateral prefrontal cortex (DLPFC).
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Who is running the clinical trial?
Massachusetts General HospitalLead Sponsor
2,814 Previous Clinical Trials
13,565,330 Total Patients Enrolled
180 Trials studying Depression
31,620 Patients Enrolled for Depression
National Institute of Mental Health (NIMH)NIH
2,664 Previous Clinical Trials
1,983,870 Total Patients Enrolled
637 Trials studying Depression
239,996 Patients Enrolled for Depression
Media Library
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Who is able to participate in this medical experiment?
"This clinical trial seeks to enrol 80 adults, aged 18 - 65 years old, who are suffering from major depressive disorder (MDD). Furthermore, applicants must be able to provide informed consent and they may have comorbid anxiety or personality disorders as long MDD is the primary diagnosis."
Answered by AI
Does this medical research encompass individuals older than eighty years of age?
"This clinical trial is looking for individuals between 18 and 65 years old to take part."
Answered by AI
Are there any enrollment opportunities currently available for this experiment?
"According to clinicaltrials.gov, the trial in question is not presently open for recruitment; this research was initially made available on January 2nd 2023 and last updated August 30th 2022. Despite that, 826 additional studies are still actively recruiting participants at this time."
Answered by AI
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