This trial is evaluating whether Personalized Remapping will improve 6 primary outcomes and 5 secondary outcomes in patients with Macular Degeneration. Measurement will happen over the course of Measured during fourth visit- each visit is one day only and this measure refers to data gathered during a < 1 hr long reading session during that day.
This trial requires 108 total participants across 2 different treatment groups
This trial involves 2 different treatments. Personalized Remapping is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.
"Age-related macular degeneration refers to the degeneration of the retina and the vision center in a person's eye, most commonly caused by old age. A person at age 85 will likely have 20/400 vision while a person in their 80s may only have 20/160 vision. A person 75 years old will have problems with peripheral vision even though they are not blind because of their age-related macular degeneration." - Anonymous Online Contributor
"Recent findings, age-related macular degeneration was frequently diagnosed in the first decade of life and was associated with poor visual function. The early detection and treatment of this eye disease may be one of the most important preventive measures." - Anonymous Online Contributor
"Age-related macular degeneration is a progressive disease with a variable natural history and no known means of treatment. Patients usually suffer considerable vision deterioration and can be effectively managed with appropriate ophthalmic care." - Anonymous Online Contributor
"Diabetes may cause age-related macular degeneration, because the retinal blood vessels are enlarged in advanced diabetes. The retina is nourished by blood from the underlying retina, which may be insufficient in advanced diabetic macular degeneration." - Anonymous Online Contributor
"A small number of ophthalmologists specialize in treating patients with macular degeneration. This number of specialists has been increasing over time. Recently, treatment for early or late stage AMD has emerged as a common area of specialization for ophthalmologists. A significant number of ophthalmologists are treating dry AMD." - Anonymous Online Contributor
"Every year in the US, around 32,000 new cases of AMD are diagnosed, making up 1.7% of American adults. About 50% of people with AMD will be diagnosed before their 60s and 80% after 80. While the burden of AMD is higher in women than in men, more men are diagnosed with cancer or stroke. It will take work to prevent the disease." - Anonymous Online Contributor
"The common side effects of conventional remapping were modestly increased photoreceptor, macular pigment pigment, and retinal pigment epithelium (RPE) alterations. The presence of macular lesions and choroidal lesions with no systemic signs may be additional risk factors for an increased frequency of adverse ocular and systemic side effects associated with conventional remapping procedures." - Anonymous Online Contributor
"An age-related macular degeneration prevention programme can help prevent blindness in those who are at high risk. However, those at low risk should be informed that the risk is not zero, and that they are likely to develop visual impairment despite the programme." - Anonymous Online Contributor
"In comparison with classic retinal mapping, traditional remapping allows the placement of larger numbers of electrode sites. Although traditional remapping results in fewer visual field defects compared with classic remapping, neither procedure improves fixation patterns. However, in patients with poor fixation patterns, traditional remapping improves visual acuity." - Anonymous Online Contributor
"Based on previous results, it is likely that patients who received either intravitreal injections of bevacizumab or ranibizumab for 12 weeks in phase 3 clinical trials experienced significant visual improvements." - Anonymous Online Contributor
"Since this technique is easy and rapid, it can be considered as a good screening tool for retinal disease in this age group when not available in a general ophthalmology practice." - Anonymous Online Contributor
"The remapping procedure in our study did not significantly improve quality of life, and, in fact, we found it had a negative impact on wellbeing of the patients and their families. Although long-term follow-up is a requirement in such procedures, we would recommend that clinicians reconsider their use. We suggest that the development of a standardised method of mapping retinal regions with a special emphasis on the optic disc edge should be investigated as this may provide a more objective and reliable indicator of visual field defects." - Anonymous Online Contributor