Visual Remapping for Age-Related Macular Degeneration

Overseen By Gordon Legge, Ph.D.

Age: Any Age

Sex: Any

Trial Phase: Academic

Sponsor: University of Minnesota

Disqualifiers: Unilateral scotomas, Poor fixation, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 9

108 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

Reading performance in patients with Central Vision Loss and age matched controls with artificial scotomas will be measured with and without different kinds of remapping of missing text to different parts of the visual field.

Who Is on the Research Team?

Stephen Engel, Ph.D.

Principal Investigator

University of Minnesota

Are You a Good Fit for This Trial?

This trial is for individuals aged 16 or older with central vision loss from age-related macular degeneration. Participants must have a stable gaze within one degree using their preferred retinal locus (PRL) and be able to calibrate an eye tracker. Those with cognitive impairment, poor fixation, or insufficient central vision loss are excluded.

Inclusion Criteria

You are able to use an eye tracker accurately.

No cognitive impairment as indicated by a Mini-Mental State Examination (MMSE).

I can keep my gaze steady using my preferred retinal location.

Exclusion Criteria

It is not possible to properly calibrate the eye tracker for accurate measurements.

I have central vision loss but can still see directly in front of me.

Poor fixation (worse than+/- 1 deg) using their PRL.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

1 visit (in-person)

Initial Assessment and Calibration

Participants undergo visual field loss characterization, scotoma mapping, and eye tracker calibration

1 week

1 visit (in-person)

Personalized Remapping and Reading Tasks

Participants perform visual tasks and reading tasks with and without remapping over multiple sessions

6 weeks

6 visits (in-person)

Follow-up

Participants are monitored for any changes in reading performance and eye movement quality

1 week

1 visit (in-person)

What Are the Treatments Tested in This Trial?

Interventions

• Personalized Remapping
• Traditional Remapping

Trial Overview The study measures reading performance in patients with Central Vision Loss. It compares the effectiveness of traditional remapping versus personalized remapping of text to different visual fields in aiding reading.

How Is the Trial Designed?

Group I: Patients with scotoma Experimental Treatment 2 Interventions

No remapping (control condition), traditional remapping, personalized remapping

Group II: Normally sighted with artificial scotoma Active Control 2 Interventions

No remapping (control condition), traditional remapping, personalized remapping

Who Is Running the Clinical Trial?

University of Minnesota

Lead Sponsor

Trials

1,459

Recruited

1,623,000+