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Stem Cell Transplantation
Stem Cell Transplant for Hemophagocytic Syndrome
N/A
Waitlist Available
Research Sponsored by Fairview University Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Patients with XLP must meet specific criteria including two or more maternally related males manifesting certain phenotypes or genetic linkage to the XLP locus
Patients receiving umbilical cord blood must have an unrelated donor with specific HLA mismatches
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
Study Summary
This trial is testing whether an unrelated donor's hematopoietic stem cells can help treat patients with life-threatening hemophagocytic disorders.
Who is the study for?
This trial is for patients under 55 with life-threatening hemophagocytic disorders like HLH, Chediak-Higashi syndrome, or XLP. They must meet specific diagnostic criteria and have a suitable stem cell donor. Excluded are those with severe other diseases, active infections, poor heart/lung/kidney function, or HIV.Check my eligibility
What is being tested?
The study tests the effectiveness of unrelated donor hematopoietic stem cell transplantation in treating hemophagocytic disorders. It aims to measure disease-free survival rates and the occurrence of graft failure and graft versus host disease post-transplantation.See study design
What are the potential side effects?
Potential side effects include complications from stem cell transplantation such as infection risk due to immune suppression, graft failure where the body doesn't accept new cells, and graft versus host disease where transplanted cells attack the patient's body.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I have XLP with a family history of related symptoms or genetic link.
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My umbilical cord blood transplant will use an unrelated donor with certain HLA mismatches.
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I have Chediak-Higashi syndrome with signs like light skin and hair, frequent infections, and unique blood cell features.
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I am 35 or younger and have a matching stem cell donor.
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I have a stable or inactive hemophagocytic disorder like HLH, XLP, Chediak-Higashi syndrome, or VAHS.
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I have VAHS, relapsed after treatment, and my condition isn't due to cancer.
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I have a fever over 38.5C, an enlarged spleen, abnormal blood or spleen findings, high triglycerides or low fibrinogen, low blood counts, hemoglobin under 9.0 g/L, and platelets under 100,000/mm3.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ up to 5 years
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
Treatment Details
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Who is running the clinical trial?
Fairview University Medical CenterLead Sponsor
6 Previous Clinical Trials
20 Total Patients Enrolled
K. Scott BakerStudy ChairFairview University Medical Center
5 Previous Clinical Trials
1,648 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I am HIV positive or have a significant active infection.My heart condition falls within normal ranges.I have a blood disorder related to my cancer.I have XLP with a family history of related symptoms or genetic link.I am between 36 and 55 years old and have a matching stem cell donor.My umbilical cord blood transplant will use an unrelated donor with certain HLA mismatches.My condition has progressed to an accelerated phase.I have a severe illness that significantly limits my life expectancy.I have Chediak-Higashi syndrome with signs like light skin and hair, frequent infections, and unique blood cell features.I am 35 or younger and have a matching stem cell donor.I have a stable or inactive hemophagocytic disorder like HLH, XLP, Chediak-Higashi syndrome, or VAHS.I have VAHS, relapsed after treatment, and my condition isn't due to cancer.I have been diagnosed with cancer.My liver or kidney function is not within normal ranges.I have a fever over 38.5C, an enlarged spleen, abnormal blood or spleen findings, high triglycerides or low fibrinogen, low blood counts, hemoglobin under 9.0 g/L, and platelets under 100,000/mm3.
Research Study Groups:
This trial has the following groups:Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Would this particular experiment be beneficial for elderly individuals?
"This particular clinical trial is testing an experimental intervention for patients between the ages of 0 and 55."
Answered by AI
Can patients who meet the qualifications join this experiment?
"This study is only open to those with x-linked lymphoproliferative syndrome that are between 0 and 55 years old. Enrollment is capped at 40 patients."
Answered by AI
Are we currently accepting volunteers for this research?
"Unfortunately, this specific trial is not currently looking for any more patients. It was initially posted on March 1st, 2000 and was last updated on June 23rd, 2005. However, there are 1652 other clinical trials that are currently recruiting."
Answered by AI
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