Low-Dose Radiation Therapy for Diffuse Large B-Cell Lymphoma
What You Need to Know Before You Apply
What is the purpose of this trial?
This prospective feasibility study evaluates a minimal residual disease (MRD)-adapted treatment strategy in patients with diffuse large B-cell lymphoma (DLBCL) receiving frontline chemoimmunotherapy. Circulating tumor DNA (ctDNA)-based MRD testing and interim positron emission tomography (PET) imaging after two cycles of therapy are used to guide treatment decisions. Patients with detectable MRD may receive low-dose radiation therapy (LDRT) to residual PET-avid disease sites in addition to standard systemic therapy, while patients with undetectable MRD continue standard frontline chemoimmunotherapy. The study aims to assess the feasibility and safety of integrating MRD-guided radiation therapy into frontline treatment of DLBCL.
Who Is on the Research Team?
Snegha Ananth, MBBS
Principal Investigator
University of Nebraska
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive frontline chemoimmunotherapy with MRD testing and interim PET imaging after two cycles. Patients with detectable MRD may receive low-dose radiation therapy.
Follow-up
Participants are monitored for safety and effectiveness after treatment, including progression-free survival and overall survival assessments.
What Are the Treatments Tested in This Trial?
Interventions
- Low-Dose Radiation Therapy (LDRT)
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
Patients with detectable circulating tumor DNA minimal residual disease (ctDNA MRD) after cycle 2 of frontline chemoimmunotherapy and residual PET-avid disease may receive low-dose radiation therapy (LDRT) to PET-positive sites in addition to standard systemic therapy.
Patients with undetectable ctDNA MRD after cycle 2 of frontline chemoimmunotherapy continue standard systemic therapy without the addition of radiation therapy.
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Nebraska
Lead Sponsor
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