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Low Intensity Focused Ultrasound for Neural Mapping

Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University of Pennsylvania
Disqualifiers: Chronic alcohol abuse, Implanted devices, Pregnancy, others
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

The current study presents a unique opportunity to measure the immediate neural responses to brief, non-therapeutic transcranial low-intensity focused ultrasound (LIFU) pulses using intracranial electrodes. By recording time-locked signals in local and distant brain regions we can characterize circuit connectivity in real-time. We will use adult patients undergoing intracranial electrophysiological monitoring in an inpatient setting as our targeted population.

Are You a Good Fit for This Trial?

Inclusion Criteria

Patients considered to be in a stable medical condition, in the opinion of the PI
I have had or will have brain electrodes implanted for epilepsy or neuropsychiatric treatment at PAH or HUP.
Patients who are able to provide informed consent and fully comply with all study requirements, in the opinion of the PI
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Exclusion Criteria

Patients with chronic alcohol abuse history
Patients with additional implanted devices, such as an aneurysm clip, large cranial plates or mesh that may intersect with ultrasonic beam path
Patients who are pregnant at the time of screening or patients who get pregnant during the course of the study
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Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

LIFU Experiment

Participants receive brief, non-therapeutic transcranial low-intensity focused ultrasound (LIFU) pulses while undergoing intracranial electrophysiological monitoring

Immediate
Inpatient setting

Follow-up

Participants are monitored for safety and effectiveness after LIFU exposure

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Low Intensity Focused Ultrasound

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: LIFU ExperimentExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Pennsylvania

Lead Sponsor

Trials
2,118
Recruited
45,270,000+

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