20 Participants NeededMy employer runs this trial

taVNS + Computerized Cognitive Training for Neurocognitive Function

(NeuroHUB Trial)

Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Medical University of South Carolina
Must be taking: Cholinesterase inhibitors, NMDA antagonists
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

The purpose of this study is to investigate whether combining transcutaneous auricular vagus nerve stimulation (taVNS) with computerized cognitive training might help improve thinking abilities and mood. Participants will self-administer these treatment in their homes and undergo pre- and post-treatment assessments of thinking abilities and mood and brain MRIs.

Who Is on the Research Team?

SA

Stephanie Aghamoosa, PhD

Principal Investigator

Medical University of South Carolina

Are You a Good Fit for This Trial?

Inclusion Criteria

I am between 45 and 80 years old.
Access to reliable Wi-Fi and a Bluetooth-enabled mobile phone or tablet with internet connection capable of supporting study procedures
I have noticed changes in my thinking or memory for at least 6 months that affect my daily life.
See 2 more

Exclusion Criteria

Positive pregnancy test for female participants if still menstruating within the past 12 months.
Prior diagnosis of Mild Cognitive Impairment or Dementia
taVNS contraindications
See 3 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1 week
1 visit (virtual)

Treatment

Participants self-administer transcutaneous auricular vagus nerve stimulation (taVNS) with computerized cognitive training (CCT) at home

2 weeks
10 sessions (self-administered)

Post-treatment Assessment

Participants undergo post-treatment assessments of thinking abilities, mood, and brain MRIs

1 week
1 visit (in-person)

Follow-up

Participants are monitored for retention, adherence, and acceptability of the treatment

2 weeks
1 visit (virtual)

What Are the Treatments Tested in This Trial?

Interventions

  • Computerized Cognitive Training
  • taVNS

How Is the Trial Designed?

1

Treatment groups

Experimental Treatment

Group I: taVNS + CCTExperimental Treatment2 Interventions

Find a Clinic Near You

Who Is Running the Clinical Trial?

Medical University of South Carolina

Lead Sponsor

Trials
994
Recruited
7,408,000+

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Collaborator

Trials
2,103
Recruited
2,760,000+

National Institutes of Health (NIH)

Collaborator

Trials
2,896
Recruited
8,053,000+