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Corticosteroid

Dexamethasone for Non-Small Cell Lung Cancer

N/A

Waitlist Available

Led By Anthony Shields

Research Sponsored by Barbara Ann Karmanos Cancer Institute

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline

Awards & highlights

Study Summary

This trial is testing the effects of dexamethasone on lung cancer patients who have not responded to previous treatment. Imaging tests will be used to see if dexamethasone affects how tumors grow and respond to treatments.

Eligible Conditions

Non-Small Cell Lung Cancer

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ day 6-9

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~day 6-9

This trial's timeline: 3 weeks for screening, Varies for treatment, and day 6-9 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in tumor SUVmax assessed by 18F-FLT PET imaging

Secondary outcome measures

Change in senescence markers in circulating tumor cells

Change in serum dexamethasone concentration

Dexamethasone withdrawal as measured by changes in tumor FLT retention

+1 more

Side effects data

From 2013 Phase 4 trial • 122 Patients • NCT01474915

Deep Vein Thrombosis

Cerebrospinal fluid leak

Fever

100%

80%

60%

40%

20%

Study treatment Arm

Ondansetron

Aprepitant

Trial Design

1Treatment groups

Experimental Treatment

Group I: Treatment (dexamethasone, 18F-FLT PET)Experimental Treatment4 Interventions

Patients receive dexamethasone PO BID on days 1-5. Patients undergo 3 18F-FLT PET scans. One scan within 7 days prior to the start of dexamethasone, one scan on day 3 after the 5th dose of dexamethasone, and one scan 6-9 days after the last dose of dexamethasone.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Positron Emission Tomography

2008

Completed Phase 2

~2240

Dexamethasone

2007

Completed Phase 4

~2590

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Barbara Ann Karmanos Cancer InstituteLead Sponsor

163 Previous Clinical Trials

9,280 Total Patients Enrolled

National Cancer Institute (NCI)NIH

13,657 Previous Clinical Trials

40,933,661 Total Patients Enrolled

Anthony ShieldsPrincipal InvestigatorBarbara Ann Karmanos Cancer Institute

2 Previous Clinical Trials

8 Total Patients Enrolled

Media Library

Dexamethasone (Corticosteroid) Clinical Trial Eligibility Overview. Trial Name: NCT02819024 — N/A

Non-Small Cell Lung Cancer Research Study Groups: Treatment (dexamethasone, 18F-FLT PET)

Non-Small Cell Lung Cancer Clinical Trial 2023: Dexamethasone Highlights & Side Effects. Trial Name: NCT02819024 — N/A

Dexamethasone (Corticosteroid) 2023 Treatment Timeline for Medical Study. Trial Name: NCT02819024 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many participants are authorized to join the trial?

"That is correct. Clinicaltrials.gov attests that this research project, which was originally posted in June 2016, still seeks participants. 10 people are needed to enrol at the single trial site for inclusion into the study."

Answered by AI

Are there any available slots for this research study?

"Affirmative. Clinicaltrials.gov attests that this medical trial, which was published on June 1st 2016, is actively recruiting patients. The team aims to enroll 10 individuals across a single site."

Answered by AI

Do other studies exist that delve into the use of Dexamethasone?

"Currently, there are 555 studies in progress concerning Dexamethasone with 143 of them being Phase 3 trials. There is a concentration of research based around Elk Grove Village, Illinois; however the drug's clinical testing spans across 18,660 different sites worldwide."

Answered by AI

What conditions typically warrant Dexamethasone usage?

"Dexamethasone is typically administered for ophthalmic and sympathic purposes. It can also be utilized to address cases of branch retinal vein occlusion, macular edema, and other eye-related issues."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Dexamethasone Effects in Patients With Refractory Non-Small Cell Lung Cancer Using FLT Positron Emission Tomography

Anthony F. Shields, MD PhD 2016. "Dexamethasone Effects in Patients With Refractory Non-Small Cell Lung Cancer Using FLT Positron Emission Tomography". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02819024.