Cardiac Rehabilitation for COVID-19
Phase-Based Progress Estimates
Effectiveness
Safety
University of California, San Francisco, San Francisco, CA
COVID-19+1 More
Cardiac Rehabilitation - BehavioralEligibility
18+
All Sexes
What conditions do you have?
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Eligibility
18+
All Sexes
What conditions do you have?
Select
Study Summary
The goal of this proof-of-concept clinical trial is to determine whether cardiac rehabilitation improves exercise capacity and chronotropic (heart rate) response to exercise among people with Long COVID. The study will include individuals with confirmed SARS-CoV-2 infection, symptoms not present prior to COVID-19 that are persistent for at least 3 months after acute infection ("Long COVID"), and who have reduced exercise capacity less than predicted and reduced heart rate response during cardiopulmonary exercise testing (CPET). In addition to the primary outcome of change in peak VO2, secondary outcomes will include change in symptoms including autonomic symptoms (COMPASS-31), anxiety (GAD-7), depression (PHQ-9), endothelial function with brachial artery flow-mediated dilation, and satisfaction (net-promotor score).
Eligible Conditions
- Long COVID
- COVID-19
Treatment Effectiveness
Effectiveness Progress
Study Objectives
2 Primary · 12 Secondary · Reporting Duration: 12 weeks
12 weeks
Net Promotor Score
Number of Cardiac Rehabilitation sessions attended
Baseline and 12 weeks
Change in Composite Autonomic Symptom Scale-31 (Compass 31) Score
Change in Generalized Anxiety Disorder Screener (GAD-7) Score
Change in Inflammation
Change in Number of Long COVID symptoms
Change in Patient Health Questionnaire-9 (PHQ-9) Score
Change in Peak VO2 (ml/kg/min)
Change in Peak VO2 (percent predicted)
Change in Proportion with peak VO2 less than 85% predicted
Change in Quality of life assessed with EuroQol (EQ-5D) Visual Analogue Scale
Change in Short Form Survey (SF-36) Score
Change in adjusted heart rate reserve
Change in flow mediated dilation of the brachial artery
Trial Safety
Safety Progress
Trial Design
1 Treatment Group
Cardiac Rehabilitation
1 of 1
Experimental Treatment
25 Total Participants · 1 Treatment Group
Primary Treatment: Cardiac Rehabilitation · No Placebo Group · N/A
Cardiac Rehabilitation
Behavioral
Experimental Group · 1 Intervention: Cardiac Rehabilitation · Intervention Types: BehavioralTreatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Cardiac Rehabilitation
2016
Completed Phase 4
~3280
Trial Logistics
Trial Timeline
Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 12 weeks
Closest Location: University of California, San Francisco · San Francisco, CA
2008First Recorded Clinical Trial
5 TrialsResearching COVID-19
688 CompletedClinical Trials
Eligibility Criteria
Age 18+ · All Participants · 6 Total Inclusion Criteria
Mark “yes” if the following statements are true for you:You must be between the ages of 18 and 50 years old.
You have been previously documented to have SARS-CoV-2 RNA positivity, documented positive antigen testing, or documented positive nucleocapsid antibody
Presence of persistent symptoms, defined as at least one COVID-attributed symptom newly present during acute illness or worse than baseline and reported to still be present for at least 90 days following symptom onset.
You are willing and able to actively participate in cardiac rehabilitation.
About The Reviewer
Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.
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