60 Participants Needed

MicroEnvironment Tumor Effects of Radiotherapy - Comprehensive Radiobiology Assessment TRial

(METEOR-CRATR Trial)

CR
Overseen ByCliff Robinson, M.D.
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Washington University School of Medicine
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

What is the purpose of this trial?

This study is a dynamically adjustable prospective longitudinal study designed to capture biospecimen (biopsy, blood, surgical) and multimodal treatment-related data (imaging, dosimetry, clinical) before, during, and after treatment with definitive-intent chemoradiotherapy for patients with locally advanced cervical and pancreatic cancer.

Research Team

CR

Cliff Robinson, M.D.

Principal Investigator

Washington University School of Medicine

Eligibility Criteria

Inclusion Criteria

My cervical cancer is in an advanced stage.
My pancreatic cancer is advanced or has spread to other parts.
I can take care of myself but might not be able to do heavy physical work.
See 1 more

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive definitive-intent chemoradiotherapy with biospecimen collection and imaging

Varies based on individual treatment plans
Multiple visits for treatment and biospecimen collection

Follow-up

Participants are monitored for changes in tumor microenvironment and safety

5 years

Treatment Details

Participant Groups
2Treatment groups
Experimental Treatment
Group I: Pancreatic CancerExperimental Treatment3 Interventions
* Patients will have blood and tumor collected at various time points throughout participation in the study. * Patients will have standard of care imaging obtained at various time points and a diffusion basis spectrum imaging (DBSI) MRI will be obtained at the end of standard of care MRI.
Group II: Cervical CancerExperimental Treatment3 Interventions
* Patients will have blood and tumor collected at various time points throughout participation in the study. * Patients will have standard of care imaging obtained at various time points and a diffusion basis spectrum imaging (DBSI) MRI will be obtained at the end of standard of care MRI.

Find a Clinic Near You

Who Is Running the Clinical Trial?

Washington University School of Medicine

Lead Sponsor

Trials
2,027
Recruited
2,353,000+

National Cancer Institute (NCI)

Collaborator

Trials
14,080
Recruited
41,180,000+
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