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Anti-adhesive Film

Anti-Adhesive Film for Tissue Adhesions

N/A

Waitlist Available

Research Sponsored by University of Calgary

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Patients ≥ 18 years of age.

Patients undergoing partial hepatectomy with high likelihood of needing repeat hepatectomy (e.g. those with colorectal liver metastasis and hepatocellular carcinoma)

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 0-4 years from initial surgery, time of repeat surgery will vary from patient to patient

Awards & highlights

Study Summary

This trial will evaluate the effectiveness of using a hyaluronan and cellulose based antiadhesive film at the time of index hepatectomy in reducing perihepatic adhesions at the time of repeat hepatic surgery.

Who is the study for?

This trial is for adults over 18 who are having part of their liver removed and might need another surgery later, like those with colorectal liver metastasis or hepatocellular carcinoma. It's not for patients whose disease can't be operated on, those who can't agree to the study themselves, or people allergic to Seprafilm or its ingredients.Check my eligibility

What is being tested?

The study tests a hyaluronan-cellulose film applied during initial liver surgery to see if it helps reduce tissue sticking together at follow-up surgeries. Participants will be randomly assigned to receive this anti-adhesive barrier or not.See study design

What are the potential side effects?

While specific side effects aren't listed here, potential risks may include allergic reactions in individuals sensitive to the film's components and complications related to adhesion barriers.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am 18 years old or older.

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I am likely to need another liver surgery due to my liver cancer or metastasis.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 0-4 years from initial surgery, time of repeat surgery will vary from patient to patient

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~0-4 years from initial surgery, time of repeat surgery will vary from patient to patient

This trial's timeline: 3 weeks for screening, Varies for treatment, and 0-4 years from initial surgery, time of repeat surgery will vary from patient to patient for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Tissue Adhesions

Secondary outcome measures

30-day mortality and morbidity

Duration of hepatic pedicle clamping

Estimated blood loss

+3 more

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: SeprafilmExperimental Treatment1 Intervention

Antiadhesion barrier applied

Group II: No seprafilmActive Control1 Intervention

No barrier applied

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of CalgaryLead Sponsor

791 Previous Clinical Trials

868,694 Total Patients Enrolled

Media Library

Adhesion barrier (Anti-adhesive Film) Clinical Trial Eligibility Overview. Trial Name: NCT04641923 — N/A

Liver Tumors Research Study Groups: Seprafilm, No seprafilm

Liver Tumors Clinical Trial 2023: Adhesion barrier Highlights & Side Effects. Trial Name: NCT04641923 — N/A

Adhesion barrier (Anti-adhesive Film) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04641923 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are individuals able to participate in this experiment currently?

"The details on clinicaltrials.gov reveal that this medical trial is no longer enrolling participants - the initial listing was posted in November of 2022 and last updated in April 2021. Nonetheless, there are currently 242 other active trials recruiting patients."

Answered by AI

Recent research and studies

Journal of Hepato-Biliary-Pancreatic SciencesJournal

A Novel Scoring System for Evaluating the Difficulty of Lysis of Adhesion and Surgical Risk at Repeat Hepatectomy

Kobayashi, Yuta, Junichi Shindoh, Yu Igata, Satoshi Okubo, and Masaji Hashimoto. 2020. “A Novel Scoring System for Evaluating the Difficulty of Lysis of Adhesion and Surgical Risk at Repeat Hepatectomy”. Journal of Hepato-biliary-pancreatic Sciences. Wiley. doi:10.1002/jhbp.708.

Annals of SurgeryJournal

Use of Bioresorbable Membranes to Reduce Abdominal and Perihepatic Adhesions in 2-stage Hepatectomy of Liver Metastases from Colorectal Cancer

Dupré, Aurélien, Anne Lefranc, Emmanuel Buc, Jean Robert Delpero, François Quenet, Guillaume Passot, Serge Evrard, and Michel Rivoire. 2013. “Use of Bioresorbable Membranes to Reduce Abdominal and Perihepatic Adhesions in 2-stage Hepatectomy of Liver Metastases from Colorectal Cancer”. Annals of Surgery. Ovid Technologies (Wolters Kluwer Health). doi:10.1097/sla.0b013e3182854949.

The American Journal of SurgeryJournal

Prevention of Postoperative Peritoneal Adhesions: A Review of the Literature

Schnüriger, Beat, Galinos Barmparas, Bernardino C. Branco, Thomas Lustenberger, Kenji Inaba, and Demetrios Demetriades. 2011. “Prevention of Postoperative Peritoneal Adhesions: A Review of the Literature”. The American Journal of Surgery. Elsevier BV. doi:10.1016/j.amjsurg.2010.02.008.

Digestive SurgeryJournal