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Programmed Intermittent Epidural Bolus for Prolonged Labor (GLEAM Trial)

N/A
Waitlist Available
Led By Ronald B George, MD
Research Sponsored by University of California, San Francisco
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Requests labor epidural analgesia requiring epidural maintenance with local anesthesia and opioid for planned vaginal delivery
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up during labor up to time of delivery
Awards & highlights

GLEAM Trial Summary

The GLEAM trial is a multicenter, pragmatic, cluster-randomized trial to assess the effects of programmed intermittent epidural bolus versus continuous epidural infusion on the rate of spontaneous vaginal delivery and several other clinically-relevant outcomes.

Eligible Conditions
  • Prolonged Labor

GLEAM Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

GLEAM Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~delivery
This trial's timeline: 3 weeks for screening, Varies for treatment, and delivery for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Spontaneous Vaginal Delivery
Secondary outcome measures
CEI rate
Cesarean Delivery
Epidural opioids used
+8 more

GLEAM Trial Design

2Treatment groups
Active Control
Group I: Programmed Intermittent Epidural BolusActive Control1 Intervention
Intermittent epidural bolus as the first line labor epidural analgesia maintenance infusion
Group II: Continuous Epidural InfusionActive Control1 Intervention
Continuous epidural infusion as the first line labor epidural analgesia maintenance infusion

Find a Location

Who is running the clinical trial?

University of California, San FranciscoLead Sponsor
2,513 Previous Clinical Trials
15,243,936 Total Patients Enrolled
Ronald B George, MDPrincipal InvestigatorUniversity of California, San Francisco
1 Previous Clinical Trials
105 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
Current Medical Research and OpinionJournal
A Retrospective Comparison of Programmed Intermittent Epidural Bolus with Continuous Epidural Infusion for Maintenance of Labor Analgesia
Tien, Michael, Terrence K. Allen, Amy Mauritz, and Ashraf S. Habib. 2016. “A Retrospective Comparison of Programmed Intermittent Epidural Bolus with Continuous Epidural Infusion for Maintenance of Labor Analgesia”. Current Medical Research and Opinion. Informa UK Limited. doi:10.1080/03007995.2016.1181619.
Anesthesia & AnalgesiaJournal
Intermittent Epidural Bolus Compared with Continuous Epidural Infusions for Labor Analgesia
George, Ronald B., Terrence K. Allen, and Ashraf S. Habib. 2013. “Intermittent Epidural Bolus Compared with Continuous Epidural Infusions for Labor Analgesia”. Anesthesia & Analgesia. Ovid Technologies (Wolters Kluwer Health). doi:10.1213/ane.0b013e3182713b26.
International Journal of Obstetric AnesthesiaJournal
Programmed Intermittent Epidural Boluses for Maintenance of Labor Analgesia: An Impact Study
McKenzie, C.P., B. Cobb, E.T. Riley, and B. Carvalho. 2016. “Programmed Intermittent Epidural Boluses for Maintenance of Labor Analgesia: An Impact Study”. International Journal of Obstetric Anesthesia. Elsevier BV. doi:10.1016/j.ijoa.2015.11.005.
Anesthesia & AnalgesiaJournal
Programmed Intermittent Epidural Bolus Versus Continuous Epidural Infusion for Labor Analgesia
Capogna, Giorgio, Michela Camorcia, Silvia Stirparo, and Alessio Farcomeni. 2011. “Programmed Intermittent Epidural Bolus Versus Continuous Epidural Infusion for Labor Analgesia”. Anesthesia & Analgesia. Ovid Technologies (Wolters Kluwer Health). doi:10.1213/ane.0b013e31822827b8.
~0 spots leftby May 2025
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