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aerobic exercise and resistance training for Kidney Failure (THESIS Trial)

N/A
Waitlist Available
Research Sponsored by St. Joseph's Healthcare Hamilton
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 10 and 20 weeks
Awards & highlights

THESIS Trial Summary

Study Hypothesis: The combination of aerobic and resistance exercise training will improve walking speed compared to either individual intervention. Brief Summary: Sixty hemodialysis participants who meet inclusion and exclusion criteria will be randomized to 20 weeks of supervised exercise, using either: (i) on-dialysis aerobic exercise using a bike ergometer; (ii) pre-dialysis leg strength training using weights; or (iii) both. The primary outcome is walking speed over 4-metres. Secondary outcomes will include: (i) short physical performance battery; (ii) health-related quality of life [EuroQOL-5D-5L]; (iii) Dialysis recovery time; (iv) Nottingham extended activities of daily living (EADL) index; (v) Leg strength; (vi) body composition and anthropometry.

Eligible Conditions
  • Kidney Failure

THESIS Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~10 and 20 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 10 and 20 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
change in walking speed over 20 weeks
Secondary outcome measures
change in EuroQOL-5D-5L over 20 weeks
change in Nottingham extended activities of daily living index over 20 weeks
change in body anthropometry and composition over 20 weeks.
+5 more

THESIS Trial Design

3Treatment groups
Experimental Treatment
Active Control
Group I: aerobic exercise and resistance trainingExperimental Treatment2 Interventions
patients will undergo a combination of aerobic exercise and resistance training on an alternating schedule three time per week
Group II: aerobic exerciseActive Control1 Intervention
patients will undergo supervised exercise on a bike ergometer for 30 minutes three times per week during hemodialysis
Group III: resistance trainingActive Control1 Intervention
patients will undergo supervised lower extremity strength training three times per week pre-hemodialysis

Find a Location

Who is running the clinical trial?

St. Joseph's Healthcare HamiltonLead Sponsor
196 Previous Clinical Trials
25,484 Total Patients Enrolled
1 Trials studying Kidney Failure
20 Patients Enrolled for Kidney Failure

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Trial of Hemodialysis Based Exercise for Strength Improvement Study
Scott Brimble 2013. "Trial of Hemodialysis Based Exercise for Strength Improvement Study". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01962597.
All > Dialysis
~5 spots leftby May 2025
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