40 Participants Needed

Exercise for Chronic Kidney Disease

JS
Overseen ByJustin Sprick, PhD
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University of North Texas, Denton, TX
Approved in 1 JurisdictionThis treatment is already approved in other countries

What You Need to Know Before You Apply

What is the purpose of this trial?

The purpose of this study is to test whether or not regular exercise training may improve brain blood flow regulation in patients with chronic kidney disease (CKD).

Do I have to stop taking my current medications for this trial?

The trial protocol does not specify whether you need to stop taking your current medications.

What safety data exists for exercise in chronic kidney disease treatment?

The safety of exercise in chronic kidney disease (CKD) has been evaluated in several studies. Exercise training has been shown to increase exercise capacity, improve muscle strength and function, decrease blood pressure, and improve inflammation and oxidative stress biomarkers. However, most studies are small, non-randomized, and non-controlled, and the effects on kidney function, cardiovascular disease, and quality of life are not well known. A single-armed interventional study in Japanese patients with stable CKD evaluated the effectiveness and safety of modest exercise, suggesting it is safe. More research is needed to develop evidence-based exercise guidelines for CKD patients.12345

Is exercise a promising treatment for chronic kidney disease?

Yes, exercise is a promising treatment for chronic kidney disease. It improves physical strength, endurance, and quality of life for patients at all stages of the disease. Exercise can also reduce healthcare costs and help patients feel more in control of their health.678910

What data supports the idea that Exercise for Chronic Kidney Disease is an effective treatment?

The available research shows that exercise can significantly improve the quality of life for people with chronic kidney disease (CKD). It helps reduce inflammation, depression, and the need for hospitalization, while also improving nutrition and overall health. Exercise is beneficial at all stages of CKD and empowers patients to take control of their health. Additionally, a study involving a 12-week exercise program showed positive impacts on patients' physical abilities and quality of life, suggesting that exercise should be a key part of CKD care.1011121314

Are You a Good Fit for This Trial?

This trial is for people with moderate to severe chronic kidney disease (stages III-IV). It's not suitable for those with heart failure, lung issues like COPD, uncontrolled blood pressure problems, pregnant women or those planning pregnancy, and individuals already exercising regularly.

Inclusion Criteria

I have moderate to severe kidney disease.
I have moderate to severe kidney disease.

Exclusion Criteria

Pregnancy or plans to become pregnant
I have chronic obstructive pulmonary disease.
You can't ride a stationary bike.
See 3 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants undergo exercise training or stretching exercises 3 times per week for 12 weeks

12 weeks
36 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Exercise
  • Stretching
Trial Overview The study is looking at how regular exercise might help the brain control blood flow in patients with chronic kidney disease. Participants will engage in supervised exercise routines including cycling and stretching exercises.
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Placebo Group
Group I: Exercise TrainingExperimental Treatment1 Intervention
Participants will exercise 3 times a week on a stationary bicycle. Exercise intensity will begin at low levels (50% of maximal heart rate reserve) and increase as tolerated to a maximum of 80% of maximal heart rate reserve. Exercise time will progress from an initial 20 minutes per session to a maximum of 45 minutes per session.
Group II: StretchingPlacebo Group1 Intervention
Participants will undergo progressive whole body stretching and balance exercises. This type of low intensity exercise is designed not to increase heart rate but rather to improve joint mobility and the ability to perform activities of daily living. This will serve as the control group to the exercise group. The control group will come in for stretching sessions 3 times per week for 20-45 minutes.

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of North Texas, Denton, TX

Lead Sponsor

Trials
13
Recruited
7,100+

Published Research Related to This Trial

Recent evidence supports the use of exercise-based rehabilitation for individuals with chronic kidney disease (CKD), highlighting its potential to improve health-related quality of life and overall outcomes.
There is a growing commitment within the kidney research community to implement practical exercise interventions, including options for prehabilitation and post-transplant rehabilitation, as well as tailored programs for those undergoing hemodialysis.
Exercise as a therapeutic intervention in chronic kidney disease: are we nearly there yet?Castle, EM., Billany, RE., Lightfoot, CJ., et al.[2023]
In a study of 130 patients with chronic kidney disease, those on renal substitution therapy for less than 6 months engaged in more physical activity compared to those diagnosed longer, suggesting early intervention may encourage activity levels.
Higher levels of moderate and vigorous physical activity were linked to better physical functioning and general health perceptions, particularly in women and patients diagnosed between 7 to 18 months, indicating that physical activity can enhance quality of life in chronic kidney disease patients.
[Association of physical activity with quality of life in patients with chronic kidney disease].Pinillos-Patiรฑo, Y., Herazo-Beltrรกn, Y., Gil Cataรฑo, J., et al.[2021]
Increased physical activity significantly improves the quality of life for patients with chronic kidney disease (CKD) and end-stage renal disease, helping to reduce inflammation, depression, and healthcare costs.
Exercise training is recommended as a crucial component of care for CKD patients at all stages, empowering them to take control of their health and improve their functional capacity.
The benefits of exercise for CKD patients.Maddux, DW., West, C.[2013]

Citations

Exercise as a therapeutic intervention in chronic kidney disease: are we nearly there yet? [2023]
[Association of physical activity with quality of life in patients with chronic kidney disease]. [2021]
The benefits of exercise for CKD patients. [2013]
Evaluation of a pragmatic exercise rehabilitation programme in chronic kidney disease. [2022]
Effect of an exercise rehabilitation program on physical function over 1 year in chronic kidney disease: an observational study. [2022]
Association of physical activity with mortality in chronic kidney disease. [2022]
Dose-response effects of physical activity on all-cause mortality and major cardiorenal outcomes in chronic kidney disease. [2022]
Moderate-Vigorous Physical Activity and Clinical Outcomes in Adults with Nondialysis Chronic Kidney Disease. [2023]
Exercise training in chronic kidney disease patients. [2022]
The effectiveness and safety of modest exercise in Japanese patients with chronic kidney disease: a single-armed interventional study. [2022]
[Physical working capacity and muscle strength in chronic renal failure are improved by exercise]. [2006]
12.United Statespubmed.ncbi.nlm.nih.gov
Exercise training in CKD: efficacy, adherence, and safety. [2022]
13.United Statespubmed.ncbi.nlm.nih.gov
Implementing exercise: what do we know? Where do we go? [2022]
14.United Statespubmed.ncbi.nlm.nih.gov
Exercise training in adults with CKD: a systematic review and meta-analysis. [2022]
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