19 Participants Needed

Resistant Starch Diet for Chronic Kidney Disease

TL
Overseen ByTawana L Gibbs, MA,MET
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

The investigators want to learn more about how to help people who have chronic kidney disease (CKD). This study will increase the investigators understanding of how diet affects factors that can slow the progression of kidney disease. The investigators are asking 30 adults and 30 children with stage 3 CKD to be part of this study. Participants will supplement their diet with resistant starch for two weeks. The investigators anticipate that the resistant starch will change the bacteria in the intestines to a more beneficial type of bacteria. The investigators will measure a product of these beneficial bacteria called butyrate. The investigators will also determine changes in the gut bacteria and products of the bacteria in the blood.

Who Is on the Research Team?

JM

John M Arthur, MD, Ph.D.

Principal Investigator

University of Arkansas

Are You a Good Fit for This Trial?

This trial is for adults aged 18-85 and children 5-17 with stage 3 chronic kidney disease (CKD), having specific levels of kidney function and protein in urine. Excluded are those under age 5 or over 85, with certain medical conditions like diabetes, recent antibiotic use, bowel diseases, past kidney transplants, pregnancy, or extreme bowel habits.

Inclusion Criteria

I am 18-85 years old with moderate kidney function and low urine protein.
I am a child aged 5-17 with moderate kidney disease and low urine protein.

Exclusion Criteria

I am under 5, have specific kidney function, or have certain health conditions or treatments.
I am not over 85, have stable kidney function, and none of the listed health issues.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants supplement their diet with resistant starch for two weeks

2 weeks
1 visit (in-person) at the start, 1 visit (in-person) at the end

Follow-up

Participants are monitored for changes in gut microbiome and blood uremic toxins

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Resistant Starch
Trial Overview The study tests if a diet supplemented with resistant starch can benefit the gut microbiome in CKD patients. It aims to see if this change improves bacterial byproducts like butyrate that might slow down CKD progression. The participants will add resistant starch to their diets for two weeks.
How Is the Trial Designed?
1Treatment groups
Experimental Treatment
Group I: Resistant StarchExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Arkansas

Lead Sponsor

Trials
500
Recruited
153,000+

National Institutes of Health (NIH)

Collaborator

Trials
2,896
Recruited
8,053,000+

National Institute of General Medical Sciences (NIGMS)

Collaborator

Trials
315
Recruited
251,000+
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