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Hormone Therapy

Treatment for Kallmann Syndrome

Phase 1
Waitlist Available
Led By Seminara B Stephanie, MD
Research Sponsored by Massachusetts General Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up frequent sampling for 2 hours
Awards & highlights

Study Summary

This trial is testing the effects of a hormone replacement on men with a condition that causes delayed puberty and low testosterone.

Eligible Conditions
  • Kallmann Syndrome
  • Hypogonadotropic Hypogonadism
  • Gonadotropin-Releasing Hormone Deficiency

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~frequent sampling for 2 hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and frequent sampling for 2 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
FSH
Inhibin B
LH
+2 more

Find a Location

Who is running the clinical trial?

Massachusetts General HospitalLead Sponsor
2,928 Previous Clinical Trials
13,198,328 Total Patients Enrolled
8 Trials studying Kallmann Syndrome
5,870 Patients Enrolled for Kallmann Syndrome
Seminara B Stephanie, MDPrincipal InvestigatorMassachusetts General Hospital

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
Endocrine ReviewsJournal
Gonadotropin-releasing Hormone Deficiency in the Human (idiopathic Hypogonadotropic Hypogonadism and Kallmann’s Syndrome): Pathophysiological and Genetic Considerations
Seminara, Stephanie B., Frances J. Hayes, and William F. Crowley Jr. 1998. “Gonadotropin-releasing Hormone Deficiency in the Human (idiopathic Hypogonadotropic Hypogonadism and Kallmann’s Syndrome): Pathophysiological and Genetic Considerations”. Endocrine Reviews. The Endocrine Society. doi:10.1210/edrv.19.5.0344.
ScienceJournal
Hypophysial Responses to Continuous and Intermittent Delivery of Hypothalamic Gonadotropin-releasing Hormone
Belchetz, P. E., T. M. Plant, Y. Nakai, E. J. Keogh, and E. Knobil. 1978. “Hypophysial Responses to Continuous and Intermittent Delivery of Hypothalamic Gonadotropin-releasing Hormone”. Science. American Association for the Advancement of Science (AAAS). doi:10.1126/science.100883.
clinicaltrials.govStudy
Studying the Effects of 7 Days of Gonadotropin Releasing Hormone (GnRH) Treatment in Men With Hypogonadism
Stephanie B. Seminara, MD 1999. "Studying the Effects of 7 Days of Gonadotropin Releasing Hormone (GnRH) Treatment in Men With Hypogonadism". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT00493961.
~1 spots leftby Apr 2025
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