Treatment for Joint Diseases

Phase-Based Estimates
1
Effectiveness
1
Safety
Sinai Hospital of Baltimore, Baltimore, MD
Joint Diseases+9 More
Eligibility
18+
All Sexes
Eligible conditions
Joint Diseases

Study Summary

This study is evaluating whether a specific type of knee replacement may help improve outcomes for patients with degenerative joint disease.

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Eligible Conditions

  • Joint Diseases
  • Osteoarthritis, Knee
  • Arthrosis
  • Osteoarthritis of the Knee
  • Osteoarthritis Knees Both
  • Osteoarthritis Knee Right
  • Osteoarthritis
  • Osteoarthritis Knee Left
  • Arthropathy of Knee Joint
  • Knee Disease
  • Knee Pain Chronic

Treatment Effectiveness

Effectiveness Estimate

1 of 3

Compared to trials

Study Objectives

This trial is evaluating whether Treatment will improve 10 primary outcomes and 7 secondary outcomes in patients with Joint Diseases. Measurement will happen over the course of Pre-operative; Post-operative - 3 month and 12 month follow-up visit.

Month 60
Post-surgical Complications
Month 60
Implant Survivorship
Month 12
Change in Active and Passive Range of Motion
Change in Anterior/Posterior Knee Translation
Change in Five Times Sit to Stand Test
Change in Initial Peak Loading Force
Change in Knee Mechanics
Change in Quadriceps Lag
Change in Quadriceps Muscle Strength
Change in Single Limb Stance Test for Both Knees
Change in Timed Ascent and Descent of One Flight of Stairs Test
Change in Timed up and Go Test (TUG)
Month 60
Change in Forgotten Joint Score FJS
Change in Knee Injury and Osteoarthritis Outcome Score (KOOS)
Change in Knee Society Score (KSS) Short Form
Change in Patient Reported Outcomes Measurement Information System (PROMIS-10)
Evidence of Osteolysis

Trial Safety

Safety Estimate

1 of 3

Compared to trials

Trial Design

2 Treatment Groups

Single Radius Design Total Knee System

This trial requires 100 total participants across 2 different treatment groups

This trial involves 2 different treatments. Treatment is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Single Radius Design Total Knee System
Device
Total Knee Arthroplasty will be done by implanting the Stryker Triathlon Tritanium Knee System into subjects.
Medial-Pivot Knee System
Device
Total Knee Arthroplasty will be done by implanting the MicroPort Medial Pivot Knee System into subjects.

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: post-operative - 6 week, 6 month, 12 month, 24 month, 36 month, and 60 month follow-up visit
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly post-operative - 6 week, 6 month, 12 month, 24 month, 36 month, and 60 month follow-up visit for reporting.

Closest Location

Sinai Hospital of Baltimore - Baltimore, MD

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 6 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Subject is indicated for a primary total knee arthroplasty (TKA) based on the approved labeling of knee implant, either a medial pivot or single radius design, specifically: MicroPort Evolution Medial-Pivot Knee System, Cruciate Retaining (CS) or Stryker Triathlon Tritanium (CS)
Subject does not have a history of previous prosthetic replacement device on the operative knee.
Subject is male or non-pregnant female aged between 18 and 75 years of age.
Subject is willing to provide informed consent to participate in the research study.
Subject is currently ambulating and does not have a condition on the contralateral limb in the opinion of the investigator that would interfere with the gait laboratory evaluations.
Subject is willing and able to comply with the schedule of events for the study and is available to return to the clinic for all required follow-up visits.

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are common treatments for joint diseases?

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These data offer comprehensive information for evaluating the clinical practice of rheumatologists and other healthcare professionals in diagnosing and treating joint disease. In addition to treatment of symptoms, patients may benefit from a correct understanding of how to prevent joint disease, which is one reason for the popularity of the journal RAI.

Unverified Answer

What are the signs of joint diseases?

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Signs of joint disease may include symptoms that are not specific to the joint. These may include joint pain, joint stiffness, swelling, loss of motion, or tenderness. The symptoms should not be due to infection and must affect an extended part of the joint. Signs of joint disease may include acute pain, arthritis, inflammation, and infection. When there is a suspicion of arthritis or acute joint pain, referral to a physical therapist is indicated since the condition is often treatable and preventable. The diagnosis should be confirmed by a medical professional when relevant, and this is often the case in an adult patient who has a history of rheumatoid arthritis.

Unverified Answer

What causes joint diseases?

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Both knee and shoulder osteoarthritis are common, with different risk factors. Pain and limitation of function are the main symptoms that influence quality of life.

Unverified Answer

How many people get joint diseases a year in the United States?

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Approximately 5% of U.S. adults will be diagnosed with an arthropathy in a given year. Most common is [osteoarthritis](https://www.withpower.com/clinical-trials/osteoarthritis). The arthritis will affect more older people and women than men. Arthritis-related disability is much higher and more severe for people with arthritis.

Unverified Answer

What is joint diseases?

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There are a great number of diseases that affect joints and can be classified into joint diseases and disorders. Most of them are degenerative or inflammatory in origin and can be classified into noninflammatory and inflammatory. Generally, noninflammatory and inflammatory diseases do not occur together, except for cartilage damage, which can occur in either of the systems. The most common are arthritis and osteoarthrosis of knee, shoulder, wrist, finger, hip, heel, ankle, foot, and shin.

Unverified Answer

Can joint diseases be cured?

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This article highlights many examples where treatment of arthritis, joint disease, or bone disease has helped other conditions such as diabetes, migraine or rheumatoid arthritis for which there is at present no cure. In order for these conditions to be effectively treated, a thorough understanding of what happens at each of these sites is required. In addition, an understanding of the interplay of the three different systems (artistry, neuroscience, and genetics) at work at each site is likely to prove an important factor in the development of a treatment model.

Unverified Answer

Who should consider clinical trials for joint diseases?

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While joint diseases tend to respond to conventional medicine therapies, there were no clinical trials evaluated in this report. Clinical trials are an effective way to seek treatments that will provide short-term benefits and long-term outcomes. A key message for patients who are considering trials is that patients should consider not just any treatment that can be used but also those treatments that are [supported by the evidence] when you have clinical trials to help guide decisions about treatments. When choosing a clinical trial, patients should be aware that it is possible or even inevitable for the treatment provided to have no effect on their disease, and their disease can progress or may progress and become permanent.

Unverified Answer

Is treatment typically used in combination with any other treatments?

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Results from a recent paper suggest that current treatments for patients with painful and functional joint conditions could be improved by combining with other treatments. More studies are needed to find out which treatments interact best with each other in this manner.

Unverified Answer

Have there been other clinical trials involving treatment?

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In all 4 trials there was limited evidence that they were successful in the short term. All were in the 'completed' or 'unpublished' stages of treatment and it was hard to imagine their conclusions would be any different. In addition to current clinical trials there are many other trials as it is becoming clear that treatments needed for osteoarthritis are not yet being implemented in clinical practice. The reasons are many and varied, yet these barriers continue to prevent the development of new treatments for osteoarthritis. However, future trials may take into account evidence gleaned from recent or current studies in order to implement more effective clinical treatments.

Unverified Answer

Have there been any new discoveries for treating joint diseases?

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Although the current treatment for joint diseases is not effective, recent clinical trials [show that new treatments may be found by doing clinical trials, and there are some clinical trials for different joint diseases are shown in "Introduction to Clinical Trials" (https://www.withpower.com/d/joint-diseases/clinical-trials).

Unverified Answer

What is treatment?

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A variety of physical treatments modulate various functions of the spine and other joints and are therefore helpful in managing disabling symptoms. A specific approach to treatment is needed with each individual patient, and each physician or chiropractor has his or her own approach.

Unverified Answer

What is the primary cause of joint diseases?

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Knee arthritis has the highest frequency of primary causes, even in younger age. Thus we should be careful about the cause and to examine the disease thoroughly and exclude the other causes whenever possible. Our understanding of the causality has been improved since we have taken into account different factors like age and duration, especially when the causality is known.

Unverified Answer
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