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Tricyclic Antidepressant

Desipramine for Irritable Bowel Syndrome

N/A
Waitlist Available
Led By Gregory S. Sayuk, MD
Research Sponsored by Washington University School of Medicine
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 month
Awards & highlights

Study Summary

This trial is looking at how pain signals in the brain relate to abdominal pain in people with irritable bowel syndrome (IBS). They will also look at how a medication, desipramine, affects these brain regions.

Eligible Conditions
  • Irritable Bowel Syndrome

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 month
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 month for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Changes in brain activations using functional MR following desipramine therapy in IBS populations.

Side effects data

From 2009 Phase 4 trial • 40 Patients • NCT00166114
14%
Headache
10%
Dry Mouth
10%
Fatigue
5%
Confusion
5%
Indigestion
5%
Heartburn
5%
Suicide gesture (superficial lacerations to wrists with a razor)
5%
Upper Respiratory Infection
5%
Sedation
5%
Irritability
100%
80%
60%
40%
20%
0%
Study treatment Arm
Escitalopram
Desipramine

Trial Design

1Treatment groups
Experimental Treatment
Group I: Open label desipramineExperimental Treatment1 Intervention
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Desipramine
FDA approved

Find a Location

Who is running the clinical trial?

Washington University School of MedicineLead Sponsor
1,937 Previous Clinical Trials
2,299,632 Total Patients Enrolled
1 Trials studying Irritable Bowel Syndrome
1 Patients Enrolled for Irritable Bowel Syndrome
Gregory S. Sayuk, MDPrincipal InvestigatorWashington University School of Medicine

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who else is applying?

What state do they live in?
West Virginia
How old are they?
65+
What site did they apply to?
Washington University School of Medicine
What portion of applicants met pre-screening criteria?
Met criteria
Recent research and studies
clinicaltrials.govStudy
Irritable Bowel Syndrome (IBS) Functional Magnetic Resonance Imaging (fMRI) With Desipramine
2009. "Irritable Bowel Syndrome (IBS) Functional Magnetic Resonance Imaging (fMRI) With Desipramine". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT00880594.
~4 spots leftby Apr 2025
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