This trialwill study the effects of hypoxia on ankle muscle activation during walking & balance in younger & older adults. Participants will switch between hypoxia & sham, and muscle activation levels will be measured. It is hypothesized that hypoxia will increase muscle activation in both groups.
- Intermittent Hypoxia
2 Primary · 0 Secondary · Reporting Duration: pre (20 minutes before) and post (20 minutes after) intermittent hypoxia or sham session
2 Treatment Groups
1 of 2
1 of 2
30 Total Participants · 2 Treatment Groups
Primary Treatment: Intermittent Hypoxia · Has Placebo Group · N/A
Who is running the clinical trial?
Age 18 - 80 · All Participants · 0 Total Inclusion CriteriaMark “Yes” if the following statements are true for you:
- Mateika JH, El-Chami M, Shaheen D, and Ivers B. Intermittent hypoxia: a low-risk research tool with therapeutic value in humans. J Appl Physiol (1985). 2015. 118(5): 520-32. Meerson F, Pozharov V, and Minyailenko T. Superresistance against hypoxia after preliminary adaptation to repeated stress. J Appl Physiol (1985). 1994. 76(5): 1856-61. Neubauer JA. Invited review: Physiological and pathophysiological responses to intermittent hypoxia. J Appl Physiol (1985). 2001. 90(4): 1593-9. Casey DP, Shepherd JR, and Joyner MJ. Sex and vasodilator responses to hypoxia at rest and during exercise. J Appl Physiol (1985). 2014. 116(7): 927-36. Casey DP, Walker BG, Curry TB, and Joyner MJ. Ageing reduces the compensatory vasodilatation during hypoxic exercise: the role of nitric oxide. J Physiol. 2011. 589(Pt 6): 1477-88. Jarrard CP, Nagel MJ, Stray-Gundersen S, Tanaka H, and Lalande S. Hypoxic preconditioning attenuates ischemia-reperfusion injury in young healthy adults. J Appl Physiol (1985). 2021. 130(3): 846-852. Nagel MJ, Jarrard CP, and Lalande S. Effect of a Single Session of Intermittent Hypoxia on Erythropoietin and Oxygen-Carrying Capacity. Int J Environ Res Public Health. 2020. 17(19). Wojan F, Stray-Gundersen S, Nagel MJ, and Lalande S. Short exposure to intermittent hypoxia increases erythropoietin levels in healthy individuals. J Appl Physiol (1985). 2021. 130(6): 1955-1960. Wesseling KH, Jansen JR, Settels JJ, and Schreuder JJ. Computation of aortic flow from pressure in humans using a nonlinear, three-element model. J Appl Physiol (1985). 1993. 74(5): 2566-73.
- Hao-Yuan Hsiao 2022. "Intermittent Hypoxia and Balance Control". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05463042.
Frequently Asked Questions
Does this research program accept participants below the age of 35?
"According to the guidelines of this clinical trial, candidates must be aged 18 or older and no more than 80 years old." - Anonymous Online Contributor
Who is eligible to enroll in this research endeavor?
"Prospective participants ought to have been diagnosed with hypoxia and be within the age range of 18-80. This medical trial is recruiting approximately 30 people." - Anonymous Online Contributor
How many participants are currently involved in this clinical experiment?
"Affirmative. According to clinicaltrials.gov, enrollment for this research is ongoing with an initial posting date of September 1st 2022 and a latest update on October 31st 2022. 30 individuals are required from one medical centre." - Anonymous Online Contributor
Are there any remaining slots open for participants in this clinical trial?
"Affirmative. The clinicaltrials.gov portal reveals that this investigation is currently recruiting patients, with the trial having first been posted on September 1st 2022 and most recently updated on October 31st 2022. This study requires 30 participants at a single location to be enrolled." - Anonymous Online Contributor