Intermittent Hypoxia for Intermittent Hypoxia

University of Texas at Austin, Austin, TX
Intermittent Hypoxia+1 More ConditionsIntermittent Hypoxia - Behavioral
18 - 80
All Sexes

Study Summary

This trialwill study the effects of hypoxia on ankle muscle activation during walking & balance in younger & older adults. Participants will switch between hypoxia & sham, and muscle activation levels will be measured. It is hypothesized that hypoxia will increase muscle activation in both groups.

Eligible Conditions
  • Intermittent Hypoxia
  • Normoxia

Treatment Effectiveness

Phase-Based Effectiveness

1 of 3

Study Objectives

2 Primary · 0 Secondary · Reporting Duration: pre (20 minutes before) and post (20 minutes after) intermittent hypoxia or sham session

pre (20 minutes before) and post (20 minutes after) intermittent hypoxia or sham session
pre (2o minutes before) and post (20 minutes after) intermittent hypoxia or sham session
Soleus muscle structure

Trial Safety

Trial Design

2 Treatment Groups

Intermittent Hypoxia
1 of 2
Normoxia (sham)
1 of 2

Experimental Treatment

Non-Treatment Group

30 Total Participants · 2 Treatment Groups

Primary Treatment: Intermittent Hypoxia · Has Placebo Group · N/A

Intermittent Hypoxia
Experimental Group · 1 Intervention: Intermittent Hypoxia · Intervention Types: Behavioral
Normoxia (sham)
ShamComparator Group · 1 Intervention: Normoxia (sham) · Intervention Types: Behavioral
First Studied
Drug Approval Stage
How many patients have taken this drug
Intermittent Hypoxia

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: pre (20 minutes before) and post (20 minutes after) intermittent hypoxia or sham session

Who is running the clinical trial?

University of Texas at AustinLead Sponsor
305 Previous Clinical Trials
69,237 Total Patients Enrolled
1 Trials studying Intermittent Hypoxia
41 Patients Enrolled for Intermittent Hypoxia

Eligibility Criteria

Age 18 - 80 · All Participants · 0 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
  • Mateika JH, El-Chami M, Shaheen D, and Ivers B. Intermittent hypoxia: a low-risk research tool with therapeutic value in humans. J Appl Physiol (1985). 2015. 118(5): 520-32. Meerson F, Pozharov V, and Minyailenko T. Superresistance against hypoxia after preliminary adaptation to repeated stress. J Appl Physiol (1985). 1994. 76(5): 1856-61. Neubauer JA. Invited review: Physiological and pathophysiological responses to intermittent hypoxia. J Appl Physiol (1985). 2001. 90(4): 1593-9. Casey DP, Shepherd JR, and Joyner MJ. Sex and vasodilator responses to hypoxia at rest and during exercise. J Appl Physiol (1985). 2014. 116(7): 927-36. Casey DP, Walker BG, Curry TB, and Joyner MJ. Ageing reduces the compensatory vasodilatation during hypoxic exercise: the role of nitric oxide. J Physiol. 2011. 589(Pt 6): 1477-88. Jarrard CP, Nagel MJ, Stray-Gundersen S, Tanaka H, and Lalande S. Hypoxic preconditioning attenuates ischemia-reperfusion injury in young healthy adults. J Appl Physiol (1985). 2021. 130(3): 846-852. Nagel MJ, Jarrard CP, and Lalande S. Effect of a Single Session of Intermittent Hypoxia on Erythropoietin and Oxygen-Carrying Capacity. Int J Environ Res Public Health. 2020. 17(19). Wojan F, Stray-Gundersen S, Nagel MJ, and Lalande S. Short exposure to intermittent hypoxia increases erythropoietin levels in healthy individuals. J Appl Physiol (1985). 2021. 130(6): 1955-1960. Wesseling KH, Jansen JR, Settels JJ, and Schreuder JJ. Computation of aortic flow from pressure in humans using a nonlinear, three-element model. J Appl Physiol (1985). 1993. 74(5): 2566-73.
  • Hao-Yuan Hsiao 2022. "Intermittent Hypoxia and Balance Control".

Frequently Asked Questions

Does this research program accept participants below the age of 35?

"According to the guidelines of this clinical trial, candidates must be aged 18 or older and no more than 80 years old." - Anonymous Online Contributor

Unverified Answer

Who is eligible to enroll in this research endeavor?

"Prospective participants ought to have been diagnosed with hypoxia and be within the age range of 18-80. This medical trial is recruiting approximately 30 people." - Anonymous Online Contributor

Unverified Answer

How many participants are currently involved in this clinical experiment?

"Affirmative. According to, enrollment for this research is ongoing with an initial posting date of September 1st 2022 and a latest update on October 31st 2022. 30 individuals are required from one medical centre." - Anonymous Online Contributor

Unverified Answer

Are there any remaining slots open for participants in this clinical trial?

"Affirmative. The portal reveals that this investigation is currently recruiting patients, with the trial having first been posted on September 1st 2022 and most recently updated on October 31st 2022. This study requires 30 participants at a single location to be enrolled." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.