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Oral Glucose Tolerance Test (OGTT) for Schizophrenia

N/A
Waitlist Available
Led By David Goldsmith, MD
Research Sponsored by Emory University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, hours 1, 2, and 3
Awards & highlights

Study Summary

This trial will test whether insulin resistance causes inflammation in people with schizophrenia or schizoaffective disorder.

Eligible Conditions
  • Schizophrenia

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, hours 1, 2, and 3
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, hours 1, 2, and 3 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Fasting Blood Glucose
Change in Fasting Blood Insulin
Change in Interleukin-1 receptor antagonist (IL-1RA) Levels
+8 more
Secondary outcome measures
Change in Cambridge Neuropsychological Test Automated Battery (CANTAB) Reaction Time Score
Change in Digit Symbol Substitution Task (DSST) Score
Change in Effort-Expenditure for Rewards Task (EEfRT) Score
+6 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: Oral Glucose Tolerance Test (OGTT)Experimental Treatment1 Intervention
Medically stable participants with schizophrenia and a range of insulin resistance will have an oral glucose tolerance test.

Find a Location

Who is running the clinical trial?

Emory UniversityLead Sponsor
1,636 Previous Clinical Trials
2,560,561 Total Patients Enrolled
9 Trials studying Schizophrenia
940 Patients Enrolled for Schizophrenia
National Institute of Mental Health (NIMH)NIH
2,782 Previous Clinical Trials
2,689,095 Total Patients Enrolled
248 Trials studying Schizophrenia
89,412 Patients Enrolled for Schizophrenia
David Goldsmith, MDPrincipal Investigator - Emory University
Emory University

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the current intake capacity for this research trial?

"Correct. According to clinicaltrials.gov, the trial that began on August 31st 2020 is still recruiting participants. Twenty individuals are needed across 6 different study centres for this initiative."

Answered by AI

Does this research program accommodate participants over the age of thirty?

"This clinical trial is looking for patients between the ages of 18 to 59. There are 73 studies specifically recruiting individuals under 18, while 431 trials focus on those over 65 years old."

Answered by AI

Are individuals from the general public currently allowed to join this experiment?

"The information hosted on clinicaltrials.gov confirms that this particular medical trial is currently enlisting participants, having been initially posted in August 2020 and most recently edited in December 2021."

Answered by AI

To whom is this clinical investigation open?

"This medical trial seeks to enrol 20 volunteers with schizophrenia aged between 18 and 59. The key selection criteria is that they must have a Brief Negative Symptom Scale Score of at least 25, no psychotropic medication changes for one month prior to study enrollment (although other medications such as antidepressants are permissible), and finally a Mini Mental Status Examination Score of 24 or higher."

Answered by AI

What results are expected from this medical experiment?

"This clinical trial's primary assessment will be a Change in Fasting Blood Glucose over the Baseline, Hours 1, 2, and 3 timespan. Secondary outcomes include Change in Resting State Scan - which involves correlating regional similarity with striatal seed region time series; Change in Effort-Expenditure for Rewards Task (EEfRT) Score - through calculating participants' choices between hard and easy tasks to obtain monetary rewards; plus a Change in neural response to anticipating and receiving monetary incentives assessed by Monetary Incentive Delay (MID) Task during fMRI neuroimaging."

Answered by AI
~3 spots leftby Apr 2025