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CenteringPregnancy for Premature Birth (PIINC Trial)

N/A

Waitlist Available

Led By Ann Border, MD, MSc

Research Sponsored by NorthShore University HealthSystem

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be younger than 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up measured at delivery

Awards & highlights

PIINC Trial Summary

This trial is studying whether group prenatal care lowers pro-inflammatory profiles compared to routine prenatal care, and if this differs by race and income.

Eligible Conditions

Premature Birth

PIINC Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ measured at delivery

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~measured at delivery

This trial's timeline: 3 weeks for screening, Varies for treatment, and measured at delivery for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Prevalence of placental chronic inflammatory lesions stratified by placental compartment - decidua vs. villous layer vs. membranes

Prevalence of placental chronic inflammatory lesions, characterized histologically

Secondary outcome measures

Concentration (pg/mL) of inflammatory cytokines in peripheral maternal blood via multiplex immunoassays

Differential expression of mRNA gene transcripts for 34,000 human genes

PIINC Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: CenteringPregnancy group prenatal careExperimental Treatment1 Intervention

Pregnant women who were randomized to receive CenteringPregnancy group prenatal care.

Group II: Traditional individual prenatal careActive Control1 Intervention

Pregnant women who were randomized to receive traditional individual prenatal care.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

CenteringPregnancy

2011

Completed Phase 3

~4580

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

NorthShore University HealthSystemLead Sponsor

132 Previous Clinical Trials

736,727 Total Patients Enrolled

4 Trials studying Premature Birth

690 Patients Enrolled for Premature Birth

Prisma Health-UpstateOTHER

82 Previous Clinical Trials

41,805 Total Patients Enrolled

2 Trials studying Premature Birth

2,390 Patients Enrolled for Premature Birth

University of California, Los AngelesOTHER

1,530 Previous Clinical Trials

10,263,554 Total Patients Enrolled

4 Trials studying Premature Birth

2,721 Patients Enrolled for Premature Birth

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any vacancies currently available for individuals interested in participating in this clinical trial?

"According to details posted on clinicaltrials.gov, this medical trial is not actively seeking patients at the moment. The investigation was initially published on August 8th 2018 and its last update came on August 15th 2022. Nonetheless, 613 other experiments require participants currently."

Answered by AI

Does this research encompass subjects of all ages, including those above twenty years?

"To be considered for this research, applicants must fall between the age range of 14 to 45. Separately, there are 210 trials available for minors and 340 studies accessible to seniors."

Answered by AI

Does my profile meet the criteria for this clinical trial?

"1150 people aged 14-45 who have experienced a premature birth may register for the trial. Those applying must be pregnant women of the aforementioned age group."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

A RCT of CenteringPregnancy on Birth Outcomes and Maternal Inflammation

Ann Borders 2018. "A RCT of CenteringPregnancy on Birth Outcomes and Maternal Inflammation". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04097548.