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Dietary Supplement

Magnesium for Inflammation

N/A

Waitlist Available

Led By Martha Shrubsole, PhD

Research Sponsored by Vanderbilt University Medical Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 12 weeks

Awards & highlights

Study Summary

This trial found that a reduction in the Ca/Mg ratio in the gut microbiome caused changes in the way that carbohydrates were fermented and energy was metabolized, which could have implications for many inflammation-related diseases or metabolic disorders.

Who is the study for?

This trial is for participants of a previous study on preventing colorectal cancer who provided stool, swab, or rectal biopsy samples. It's not open to those who didn't provide these samples in the earlier study.Check my eligibility

What is being tested?

The trial is testing whether changing the balance of calcium and magnesium affects gut bacteria and inflammation which might be linked to colorectal cancer and other diseases related to metabolism.See study design

What are the potential side effects?

Since this trial involves dietary supplements like Magnesium glycinate compared with a placebo, side effects may include digestive discomfort or changes in bowel habits.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 12 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~12 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Conduct metagenomic analysis of stool, rectal swab, and rectal mucosa samples

Immunohistochemistry for necroptosis-related biomarkers

Quantitative PCR for Bifidobacterium and Lactobacillus

Trial Design

4Treatment groups

Active Control

Placebo Group

Group I: GG genotype and magnesium treatmentActive Control1 Intervention

Participants who have the GG genotype will be assigned to magnesium glycinate

Group II: GA/AA genotype and magnesium treatmentActive Control1 Intervention

Participants who have the GA/AA genotype will be assigned to magnesium glycinate

Group III: GA/AA genotype and PlaceboPlacebo Group1 Intervention

Participants who have the GA/AA genotype will be assigned to placebo group

Group IV: GG genotype and placeboPlacebo Group1 Intervention

Participants who have the GG genotype will be assigned to placebo group

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Vanderbilt University Medical CenterLead Sponsor

856 Previous Clinical Trials

671,952 Total Patients Enrolled

Martha Shrubsole, PhDPrincipal InvestigatorVanderbilt University

Media Library

Magnesium glycinate (Dietary Supplement) Clinical Trial Eligibility Overview. Trial Name: NCT04229992 — N/A

Colorectal Cancer Research Study Groups: GG genotype and magnesium treatment, GA/AA genotype and Placebo, GA/AA genotype and magnesium treatment, GG genotype and placebo

Colorectal Cancer Clinical Trial 2023: Magnesium glycinate Highlights & Side Effects. Trial Name: NCT04229992 — N/A

Magnesium glycinate (Dietary Supplement) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04229992 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who would be a suitable candidate to join this experiment?

"Patients aged between 40 and 85, who are suffering from inflammation, can enroll in this trial. Our team's goal is to accept a total of 240 participants into the study."

Answered by AI

Is this clinical research recruiting participants at the present moment?

"According to clinicaltrials.gov, recruitment for this particular trial has been closed since March 31st 2022 after opening on May 5th 2017. Despite being inactive, there are still 966 other medical trials actively seeking enrolment at the present moment."

Answered by AI

Is the participant eligibility limited to adults under 30 years of age for this investigation?

"According to the criteria, individuals aged 40 and above are qualified for this trial; however, those who have exceeded 85 years old cannot participate."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Calcium: Magnesium Balance, Microbiota, and Necroptosis and Inflammation

Martha Shrubsole 2017. "Calcium: Magnesium Balance, Microbiota, and Necroptosis and Inflammation". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04229992.