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Diesel Exhaust and stress for Catecholamines (DESTRESS Trial)

N/A
Waitlist Available
Led By Anjum Hajat, PhD
Research Sponsored by University of Washington
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Non-smokers without history of high blood pressure, asthma, diabetes, high cholesterol, post-traumatic stress disorder (PTSD) or any other chronic condition that requires ongoing care.
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change in blood pressure from baseline (pre-exposure) to 60 minutes post exposure
Awards & highlights

DESTRESS Trial Summary

This study uses an experimental design to conduct a double-blind, randomized, crossover study where participants receive both diesel exhaust and a mental stress test in a controlled setting. My hypothesis is that the synergistic effect of stress and air pollution will result in higher levels of stress and inflammation (measured via biological markers) as well as poorer cardiovascular disease related outcomes compared to the independent effect of each exposure separately.

Eligible Conditions
  • Catecholamines
  • High Blood Pressure
  • Inflammation

DESTRESS Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

DESTRESS Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change in dopamine from baseline (pre-exposure) to immediately after exposure
This trial's timeline: 3 weeks for screening, Varies for treatment, and change in dopamine from baseline (pre-exposure) to immediately after exposure for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in dopamine
Change in epinephrine
Change in norepinephrine
Secondary outcome measures
Change in d-dimer
Change in fibrinogen
Change in interleukin-1b (IL-1b)
+2 more
Other outcome measures
Change in blood pressure
Change in heart rate

DESTRESS Trial Design

4Treatment groups
Active Control
Group I: Diesel Exhaust and stressActive Control2 Interventions
Subjects sit in a room for two hours breathing in diesel exhaust at 200 micrograms of meter cubed and are subject to a mental stress test (TSST) which involves a public speaking and math task.
Group II: TSST/Stress onlyActive Control1 Intervention
Subjects undergo a mental stress test, known as the Trier Social Stress Test (TSST), which involves a public speaking and math task.
Group III: Diesel ExhaustActive Control1 Intervention
Subjects sit in a room for two hours breathing in diesel exhaust at 200 micrograms of meter cubed.
Group IV: Filtered AirActive Control1 Intervention
Subjects sit in a room for two hours breathing in filtered air which resembles levels of air pollution found in the ambient environment

Find a Location

Who is running the clinical trial?

University of WashingtonLead Sponsor
1,740 Previous Clinical Trials
1,847,916 Total Patients Enrolled
National Institute of Environmental Health Sciences (NIEHS)NIH
284 Previous Clinical Trials
1,232,715 Total Patients Enrolled
Anjum Hajat, PhDPrincipal InvestigatorUniversity of Washington

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Mental Stress & Diesel Exhaust on Cardiovascular Health
Anjum Hajat 2018. "Mental Stress & Diesel Exhaust on Cardiovascular Health". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03467997.
All > Cardiovascular
~3 spots leftby Apr 2025
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