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Sleep deprivation for Sleep Deprivation (SASH Trial)

N/A
Waitlist Available
Led By Sanjay R Patel, MD
Research Sponsored by University of Pittsburgh
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline sleep replete state and after 24 hours of sleep deprivation
Awards & highlights

SASH Trial Summary

This study is evaluating whether sleep deprivation in people living with HIV leads to an increase in inflammation and endothelial dysfunction.

Eligible Conditions
  • Sleep Deprivation
  • Inflammation
  • HIV

SASH Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline sleep replete state and after 24 hours of sleep deprivation
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline sleep replete state and after 24 hours of sleep deprivation for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
IL6
Soluble CD14
Soluble CD163
Secondary outcome measures
CD4+ T-cell Expression of HLA-DR and CD38
CD8+ T-cell Expression of HLA-DR and CD38
Flow Mediated Brachial Artery Dilation
+2 more
Other outcome measures
CD4+ T-cell Expression of CD39 and/or CD73
CD8+ T-cell Expression of CD39 and/or CD73
Plasma Adenosine
+2 more

SASH Trial Design

1Treatment groups
Experimental Treatment
Group I: Sleep deprivationExperimental Treatment1 Intervention
All subjects will be provided an 8 hour opportunity for sleep (Night 1) followed by outcome assessment the next morning (Day 1). They will then be kept awake the subsequent 24 hours including Night 2, followed by outcome assessment the following morning (Day 2).
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Sleep deprivation
2016
N/A
~830

Find a Location

Who is running the clinical trial?

University of PittsburghLead Sponsor
1,719 Previous Clinical Trials
16,342,321 Total Patients Enrolled
6 Trials studying Sleep Deprivation
388 Patients Enrolled for Sleep Deprivation
National Heart, Lung, and Blood Institute (NHLBI)NIH
3,831 Previous Clinical Trials
47,306,072 Total Patients Enrolled
11 Trials studying Sleep Deprivation
4,789 Patients Enrolled for Sleep Deprivation
Sanjay R Patel, MDPrincipal InvestigatorUniversity of Pittsburgh
1 Previous Clinical Trials
53 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Poor Sleep and Inflammation in HIV-Infected Adults
Sanjay R Patel 2020. "Poor Sleep and Inflammation in HIV-Infected Adults". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03848325.
~5 spots leftby Apr 2025
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