Sleep deprivation for Inflammation

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
University of Pittsburgh, Pittsburgh, PA
Inflammation+3 More
Sleep deprivation - Behavioral
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

This study is evaluating whether sleep deprivation in people living with HIV leads to an increase in inflammation and endothelial dysfunction.

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Eligible Conditions

  • Inflammation
  • Human Immunodeficiency Virus Type 1 (HIV-1) Infection
  • Sleep Debt

Treatment Effectiveness

Effectiveness Progress

1 of 3

Other trials for Inflammation

Study Objectives

This trial is evaluating whether Sleep deprivation will improve 3 primary outcomes, 5 secondary outcomes, and 5 other outcomes in patients with Inflammation. Measurement will happen over the course of Baseline and immediately after sleep deprivation.

Baseline and immediately after sleep deprivation
Change in CD4+ T-cell expression of CD39 and/or CD73
Change in CD4+ T-cell expression of HLA-DR and CD38
Change in CD8+ T-cell expression of CD39 and/or CD73
Change in CD8+ T-cell expression of HLA-DR and CD38
Change in IL6
Change in flow mediated brachial artery dilation
Change in monocyte expression of IL6
Change in monocyte expression of TNF-alpha
Change in plasma adenosine
Change in plasma inosine
Change in soluble CD14
Change in soluble CD163
Change in urine 3'5'-cAMP

Trial Safety

Safety Progress

1 of 3

Other trials for Inflammation

Trial Design

1 Treatment Group

Sleep deprivation
1 of 1
Experimental Treatment

This trial requires 40 total participants across 1 different treatment group

This trial involves a single treatment. Sleep Deprivation is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Sleep deprivation
Behavioral
All subjects will be provided an 8 hour opportunity for sleep (Night 1) followed by outcome assessment the next morning (Day 1). They will then be kept awake the subsequent 24 hours including Night 2, followed by outcome assessment the following morning (Day 2).
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Sleep deprivation
2016
N/A
~500

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: baseline and immediately after sleep deprivation
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly baseline and immediately after sleep deprivation for reporting.

Who is running the study

Principal Investigator
S. R. P.
Prof. Sanjay R Patel, Professor
University of Pittsburgh

Closest Location

University of Pittsburgh - Pittsburgh, PA

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 3 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
HIV positive
On continuous anti-retroviral therapy regimen for at least 48 weeks
CD4+ cell count greater than or equal to 200 cells/mm^3

Patient Q&A Section

Does sleep debt run in families?

"There is an elevated level of sleep debt in families with an history of child morbidity, but not in the control families. The level of sleep debt is not related to the incidence of morbidity in the family." - Anonymous Online Contributor

Unverified Answer

Is sleep deprivation safe for people?

"Among the general population, daytime tiredness is very common, while sleepiness is associated with significant impairments in safety-critical tasks among nightshift workers. In all, sleep debt is associated with a wide range of health problems. Because sleep debt and associated impairments are exacerbated by daytime functioning, and the association between sleep debt and impairment and impairments are greater during the night than during the day, sleep debt should be considered a major public health concern." - Anonymous Online Contributor

Unverified Answer

Can sleep debt be cured?

"There do not appear to be differences in the sleep debt between those who recover from insomnia and those who do not. There was no relationship between poor recovery and sleep debt, which questions the notion that sleep debt is a cause of insomnia. There were no differences between the participants who were successfully treated for insomnia and those who became chronically sleep deprived." - Anonymous Online Contributor

Unverified Answer

What are common treatments for sleep debt?

"In the United States, sleep debt is often treated using sleep hygiene techniques such as exercise, sleep restriction, and sleep restriction therapy. Furthermore, sleep recovery sleep is commonly prescribed to reduce the number of sleepless days in order to reduce sleep debt. Finally, there are many alternative therapies that have been shown to reduce sleep debt, including relaxation therapy and cognitive behavior therapy." - Anonymous Online Contributor

Unverified Answer

How many people get sleep debt a year in the United States?

"About 24 million Americans spend an average of 6 hours or less in 5 days a week. About 5 million spend less than 30 minutes per night sleeping, and another 9 million spend between 80 and 114 minutes per night. With nearly two-thirds of American adults sleeping less than 40 minutes or more than 114 minutes a night, sleep debt is prevalent in the United States and merits careful attention." - Anonymous Online Contributor

Unverified Answer

What causes sleep debt?

"It seems that sleep debt has its peak early every day, a trait associated with insomnia and an increased propensity to developing sleep debt. The sleep debt model can account for the circadian rhythm of sleep debt and its influence on the course of circadian sleep debt." - Anonymous Online Contributor

Unverified Answer

What is sleep debt?

"Sleep debt is a common issue, with frequent sleep disruption that can lead to decreased work efficiency and increased risk of occupational injury, which puts people at greater risk for heart disease, diabetes, and some cancers." - Anonymous Online Contributor

Unverified Answer

What are the signs of sleep debt?

"Among older individuals with sleep debt, sleep duration was shorter for many days. Sleep debt should be considered by physicians when evaluating insomnia in older individuals." - Anonymous Online Contributor

Unverified Answer

What is the primary cause of sleep debt?

"Results have shown that sleep debt and excessive sleepiness is associated with increased use of technology and other technological devices. Sleep debt could be the primary cause of sleep debt. Future research should be done to determine if reducing use of technology during the evening can lead to an increase in sleep debt." - Anonymous Online Contributor

Unverified Answer

How serious can sleep debt be?

"There is a growing need for information on the seriousness of sleep debt and for treatments for it. Such information is often lacking but it is critical for patients and their caregivers to be aware of this growing threat." - Anonymous Online Contributor

Unverified Answer

Does sleep deprivation improve quality of life for those with sleep debt?

"In the present exploratory study, participants with sleep debt reported lower overall QoL (as measured by SWALQ) and higher stress than did their non-deprived counterparts. Additionally an increase in subjective sleep quality for the sleep deprivation group relative to the non-deprived group was a significant finding that may lead to further study of objective measures related to QoL in future studies." - Anonymous Online Contributor

Unverified Answer

What are the latest developments in sleep deprivation for therapeutic use?

"These current advances are highly promising for the future in this therapeutic area. Further investigations are needed to establish the ultimate therapeutic efficacy and dosage in order to develop safe and effective methods." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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