Acute Intermittent Hypoxia for Anoxia

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
University of Colorado, Boulder, CO
Anoxia+2 More
Acute Intermittent Hypoxia - Other
Eligibility
18+
All Sexes
What conditions do you have?
Select

Study Summary

The goal of this pilot study is to examine the effect of repetitive acute intermittent hypoxia on motor learning in persons with chronic, incomplete spinal cord injury.

Eligible Conditions

  • Anoxia
  • Spinal Cord

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

5 Primary · 2 Secondary · Reporting Duration: We will measure TMS before the start of 5 consecutive days of AIH treatment. We will measure TMS within 24 hours of the final AIH treatment.

Hour 24
Change Muscle Surface Electromyography
Hour 24
Change in the Transcranial Magnetic Stimulation Recruitment Curve Slope
Hour 24
Change in Step Length Asymmetry
Change in Step Time Asymmetry
Hour 24
Change in Leg Kinematics
Hour 24
Change in Metabolic Power
Hour 24
Change in Metabolic Power Consumption

Trial Safety

Safety Progress

1 of 3

Trial Design

2 Treatment Groups

Repetitive Acute Intermittent Hypoxia
1 of 2
SHAM Acute Intermittent Hypoxia
1 of 2
Experimental Treatment
Non-Treatment Group

12 Total Participants · 2 Treatment Groups

Primary Treatment: Acute Intermittent Hypoxia · Has Placebo Group · N/A

Repetitive Acute Intermittent Hypoxia
Other
Experimental Group · 1 Intervention: Acute Intermittent Hypoxia · Intervention Types: Other
SHAM Acute Intermittent Hypoxia
Other
ShamComparator Group · 1 Intervention: SHAM Acute Intermittent Hypoxia · Intervention Types: Other

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: we will measure tms before the start of 5 consecutive days of aih treatment. we will measure tms within 24 hours of the final aih treatment.
Closest Location: University of Colorado · Boulder, CO
Photo of Houston University of Colorado 1Photo of Houston University of Colorado 2Photo of Houston University of Colorado 3
2007First Recorded Clinical Trial
0 TrialsResearching Anoxia
334 CompletedClinical Trials

Who is running the clinical trial?

Medical University of South CarolinaOTHER
828 Previous Clinical Trials
5,371,841 Total Patients Enrolled
University of Colorado, DenverOTHER
1,554 Previous Clinical Trials
1,910,516 Total Patients Enrolled
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)NIH
1,785 Previous Clinical Trials
2,221,786 Total Patients Enrolled
University of Colorado, BoulderLead Sponsor
108 Previous Clinical Trials
27,962 Total Patients Enrolled

Eligibility Criteria

Age 18+ · All Participants · 6 Total Inclusion Criteria

Mark “yes” if the following statements are true for you:
You have a motor-incomplete spinal cord injury at or below C2 and at or above L5.
You have the ability to advance one step overground with or without assistive devices.

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: August 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.